The Human Milk Metabolome Reveals Diverse Oligosaccharide Profiles
The Human Milk Metabolome Reveals Diverse Oligosaccharide Profiles
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DOI：
10.3945/jn.113.178772
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发表时间：
2013-11-01
影响因子：
4.2
通讯作者：
Supsky, Carolyn M.
中科院分区：
文献类型：
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作者：
Smilowitz, Jennifer T.;O'Sullivan, Aifric;Supsky, Carolyn M.
母乳为发育中的婴儿提供营养和保护。对高分子量牛奶成分的研究已经相当多，但是，低分子量代谢物受到的关注较少。为了确定母体表型和饮食对母乳代谢组的影响，通过使用质子核磁共振光谱分析从52名健康女性产后90天收集的乳汁。对65种乳汁代谢物进行了定量（单糖、二糖和寡糖;氨基酸及其衍生物;能量代谢物;脂肪酸及其相关代谢物、维生素、核苷酸及其衍生物;以及其他）。生物学变异，表示为每种代谢物的CV百分比，变化很大（4-120%），有几种代谢物的变异很小（
Breast milk delivers nutrition and protection to the developing infant. There has been considerable research on the high-molecular-weight milk components; however, low-molecular-weight metabolites have received less attention. To determine the effect of maternal phenotype and diet on the human milk metabolome, milk collected at day 90 postpartum from 52 healthy women was analyzed by using proton nuclear magnetic resonance spectroscopy. Sixty-five milk metabolites were quantified (mono-, di-, and oligosaccharides; amino acids and derivatives; energy metabolites; fatty acids and associated metabolites, vitamins, nucleotides, and derivatives; and others). The biological variation, represented as the percentage CV of each metabolite, varied widely (4-120%), with several metabolites having low variation (