Clinical efficacy and safety of topical versus oral ivermectin in treatment of uncomplicated scabies
Clinical efficacy and safety of topical versus oral ivermectin in treatment of uncomplicated scabies
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DOI：
10.1111/dth.12310
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发表时间：
2016-01-01
影响因子：
3.6
通讯作者：
Abdel-Aziz, Rasha T.
中科院分区：
文献类型：
--
作者：
Ahmad, Hesham M.;Abdel-Azim, Eman S.;Abdel-Aziz, Rasha T.
有许多药物可用于治疗疮疮，包括口服和外用伊维菌素。然而，将这两种形式作为治疗疮疮的方法进行比较的研究很少。本研究比较了外用伊维菌素和口服伊维菌素治疗溃疡病的有效性和安全性。这项研究包括62名确诊的无并发症的溃疡病患者，分为：I组(32名患者，外用伊维菌素)和II组(30名患者，口服伊维菌素)。分别于第1、2、4周对患者进行临床和KOH涂片评估。持续感染的患者在一周后重复治疗。记录不良事件。大多数患者(I组和II组分别为87.5%和73.5%)经一次治疗后症状消失。I组4例、II组8例再次治疗，治疗2周后症状、体征全部消失，4周未见复发。这项研究表明，外用伊维菌素和口服伊维菌素在治疗不复杂的溃烂方面都是安全和同样有效的。单一治疗，无论是局部治疗还是口服治疗，与治疗后一周内的高治愈率相关。然而，可能需要在一周后重复治疗才能100%治愈。
Many medications are available for scabies treatment including oral and topical ivermectin. However, studies comparing these two forms as a scabies treatment are few. This study compares efficacy and safety of topical versus oral ivermectin as scabies treatment. The study included 62 confirmed uncomplicated scabies patients, divided into: Group I (32 patients, received topical ivermectin) and Group II (30 patients, received oral ivermectin). Patients were assessed, clinically and by KOH smear at 1, 2 and 4 weeks. Treatment was repeated after one week in patients with persistent infection. Adverse events were recorded. Most patients (87.5% and 73.5% in group I and group II respectively) were symptom free after a single treatment. A second treatment was required in 4 patients of group I and 8 patients of group II. However, 2 weeks after treatment symptoms and signs completely resolved in all cases with no recurrence at 4 weeks. This study suggests that both topical and oral ivermectin are safe and equally effective in treatment of uncomplicated scabies. Single treatment, whether topical or oral, is associated with high cure rate in a week post treatment. However, repeating treatment after one week may be required to achieve 100% cure.