Does childhood misfortune raise the risk of acute myocardial infarction in adulthood?
Does childhood misfortune raise the risk of acute myocardial infarction in adulthood?
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DOI：
10.1016/j.socscimed.2013.11.026
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发表时间：
2014-03-01
影响因子：
5.4
通讯作者：
Ferraro, Kenneth F.
中科院分区：
文献类型：
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作者：
Morton, Patricia M.;Mustillo, Sarah A.;Ferraro, Kenneth F.
尽管大多数关于急性心肌梗死（AMI）的研究都集中在更近端的影响上，如成人健康行为，但本研究探讨了AMI的早期起源。纵向数据来自美国全国中年发展调查（N = 3032），这是一项具有全国代表性的调查，调查对象为25-74岁的男性和女性，时间跨度为1995年至2005年。一系列事件历史分析模型首次AMI的年龄调查了累积和单独的童年不幸领域的直接影响，以及成人健康生活方式和心理社会因素的中介作用。研究结果显示，累积的童年不幸和儿童虐待增加了AMI的风险，包括AMI家族史在内的几个成人协变量。吸烟完全调节了累积的童年不幸和儿童虐待的影响。这些发现揭示了AMI的早期起源和健康行为作为中介因素的重要性。(C) 2013 Elsevier Ltd.版权所有。
Whereas most research on acute myocardial infarction (AMI) has focused on more proximal influences, such as adult health behaviors, the present study examines the early origins of AMI. Longitudinal data were drawn from the National Survey of Midlife Development in the United States (N = 3032), a nationally representative survey of men and women aged 25-74, which spans from 1995 to 2005. A series of event history analyses modeling age of first AMI investigated the direct effects of accumulated and separate domains of childhood misfortune as well as the mediating effects of adult health lifestyle and psychosocial factors. Findings reveal that accumulated childhood misfortune and child maltreatment increased AMI risk, net of several adult covariates, including family history of AMI. Smoking fully mediated the effects of both accumulated childhood misfortune and child maltreatment. These findings reveal the importance of the early origins of AMI and health behaviors as mediating factors. (C) 2013 Elsevier Ltd. All rights reserved.