Aspirin and epithelial ovarian cancer
Aspirin and epithelial ovarian cancer
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DOI：
10.1006/pmed.2001.0945
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发表时间：
2001-12-01
影响因子：
5.1
通讯作者：
Shore, RE
中科院分区：
文献类型：
--
作者：
Akhmedkhanov, A;Toniolo, P;Shore, RE
背景流行病学证据表明，慢性炎症可能会影响卵巢癌的发生。本研究的目的是探讨常用的抗炎药阿司匹林与上皮性卵巢癌之间的关系。作者在1985年至1991年在纽约市登记的纽约大学妇女健康研究队列中进行了一项简单对照研究。经过12年的中位随访期，确定了68例上皮性卵巢癌的发病病例。在1994-1996年的随访问卷中收集了关于定期服用阿司匹林的数据。采用病例对照研究设计，在年龄和绝经状态与病例匹配的研究参与者中，每例随机选择10名对照。采用条件Logistic回归分析方法，分析阿司匹林与卵巢上皮性癌的关系，计算OR值和95%可信区间（CI）。相对于不使用阿司匹林，在调整初潮年龄、产次、口服避孕药使用和50岁之前乳腺癌一级家族史后，报告每周使用阿司匹林3次或以上、持续至少6个月的女性中，上皮性卵巢癌的OR为0.60（95%CI 0.26，1.38）。在最近、过去5年内服用阿司匹林者中，调整OR为0.36（95%CI为0.11，1.18）。虽然置信区间包括统一，但观察到的风险估计似乎与以前的研究一致，表明定期使用阿司匹林可能与上皮性卵巢癌的风险呈负相关。(C)2001年美国健康基金会和爱思唯尔科学。
Background. Epidemiological evidence suggests that chronic inflammation may influence ovarian carcinogenesis. The study objective was to examine the association between the commonly used anti-inflammatory drug aspirin and epithelial ovarian cancer.Methods. The authors conducted a ease-control study based in the New York University Women's Health Study cohort enrolled between 1985 and 1991 in New York City. After a median follow-up period of 12 years, 68 incident cases of epithelial ovarian cancer were identified. Data about regular aspirin use were collected during the 1994-1996 follow-up questionnaire. Using a case-control study design, 10 controls per case were randomly selected among study participants who matched the case by age and menopausal status. Conditional logistic regression analysis was used to study the relationships between aspirin and epithelial ovarian cancer by generating odds ratios (ORs) and 95% confidence intervals (CIs).Results. Relative to no aspirin use, the OR for epithelial ovarian cancer among women who reported aspirin use three or more times per week for a period of at least 6 months was 0.60 (95% CI 0.26, 1.38), after adjustment for age at menarche, parity, oral contraceptive use, and first-degree family history of breast cancer before age 50. Among recent, within the previous 5 years, users of aspirin, the adjusted OR was 0.36 (95% CI 0.11, 1.18).Conclusion. Although confidence intervals included unity, the observed risk estimates seem to be compatible with previous studies suggesting that regular aspirin use could be inversely associated with risk of epithelial ovarian cancer. (C) 2001 American Health Foundation and Elsevier Science.