Retinoic Acid Signaling Regulates the Metamorphosis of Feather Stars (Crinoidea, Echinodermata): Insight into the Evolution of the Animal Life Cycle
Retinoic Acid Signaling Regulates the Metamorphosis of Feather Stars (Crinoidea, Echinodermata): Insight into the Evolution of the Animal Life Cycle
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DOI：
10.3390/biom10010037
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发表时间：
2020-01-01
期刊：
影响因子：
5.5
通讯作者：
Wada, Hiroshi
中科院分区：
文献类型：
--
作者：
Yamakawa, Shumpei;Morino, Yoshiaki;Wada, Hiroshi
许多海洋无脊椎动物都有浮游幼虫的生活史，尽管这种生活史的演变仍然是个谜。我们最近提出，水母(Cnidaria)和海星(棘皮动物)之间生命周期转换的调节机制是保守的；维甲酸(RA)信号分别调节柱头和变态。然而，在这种背景下，RA信号在其他动物群体中的功能却知之甚少。在这里，为了确定RA信号在棘皮动物中的祖先功能，我们研究了RA信号在锯齿羽星变态过程中的作用。虽然羽星的幼体形态与海星不同，但我们发现外源维甲酸处理可以诱导海星幼虫发生变态，就像海星一样。此外，阻断RA合成或与RA受体结合可抑制变态。这些结果表明，RA信号在棘皮动物祖先的变态过程中起着调节作用。我们的数据从RA信号的角度为动物生命周期的进化提供了洞察力。
Many marine invertebrates have a life cycle with planktonic larvae, although the evolution of this type of life cycle remains enigmatic. We recently proposed that the regulatory mechanism of life cycle transition is conserved between jellyfish (Cnidaria) and starfish (Echinoderm); retinoic acid (RA) signaling regulates strobilation and metamorphosis, respectively. However, the function of RA signaling in other animal groups is poorly understood in this context. Here, to determine the ancestral function of RA signaling in echinoderms, we investigated the role of RA signaling during the metamorphosis of the feather star, Antedon serrata (Crinoidea, Echinodermata). Although feather stars have different larval forms from starfish, we found that exogenous RA treatment on doliolaria larvae induced metamorphosis, like in starfish. Furthermore, blocking RA synthesis or binding to the RA receptor suppressed metamorphosis. These results suggested that RA signaling functions as a regulator of metamorphosis in the ancestor of echinoderms. Our data provides insight into the evolution of the animal life cycle from the viewpoint of RA signaling.