Paraganglioma of the cauda equina: an ultrastructural and immunohistochemical study of two cases.
Paraganglioma of the cauda equina: an ultrastructural and immunohistochemical study of two cases.
复制标题
马尾副神经节瘤：两例的超微结构和免疫组织化学研究。
DOI：
10.3109/01913128809058221
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发表时间：
1988
影响因子：
1
通讯作者：
K. Hizawa
中科院分区：
文献类型：
--
作者：
T. Hirose;T. Sano;Keiichiro Mori;N. Kagawa;A. Sakaki;Yasuko Kuwamura;K. Hizawa
本文报告2例马尾神经副神经节瘤的超微结构和免疫组化特点。在这两种情况下，肿瘤细胞排列在小巢或索，并含有特征性的神经分泌颗粒，粗面内质网（RER）的层状堆栈，和一些发达的高尔基体在他们的细胞质。这些细胞的电子密度各不相同;深色细胞，偶尔类似于支持细胞，可能是脱水的浅色细胞，因为它们含有一些神经分泌颗粒。电镜下难以识别支持细胞，但免疫组化染色发现支持细胞内有不规则分布的S-100蛋白和胶质细胞酸性蛋白（GFAP）。许多肿瘤细胞含有丰富的神经丝。奇怪的是，在1例中发现了少量细胞角蛋白阳性细胞。显微镜下发现1例副神经节瘤旁有小范围的神经节细胞瘤。神经节分化的结论是常见的副神经节瘤的马尾区在十二指肠副神经节瘤。
The ultrastructural and immunohistochemical features of 2 paragangliomas arising in the cauda equina are described. In both cases the tumor cells were arranged in small nests or cords and contained characteristic neurosecretory granules, lamellar stacks of rough endoplasmic reticulum (RER), and some well-developed Golgi apparatuses in their cytoplasm. The cells varied in electron density; the darker cells, occasionally resembling sustentacular cells, were probably dehydrated light cells because they contained a few neurosecretory granules. Sustentacular cells were difficult to identify by electron microscopy, but irregularly distributed S-100 protein and glial fibrillary acidic protein (GFAP) were found in these cells by immunostaining. Many tumor cells contained abundant neurofilaments. Curiously, a few cytokeratin-positive cells were found in 1 case. On microscopic examination, a small area of ganglioneuroma was found associated with the paraganglioma in 1 case. Ganglionic differentiation was concluded to be frequent in paragangliomas of the cauda equina region as in duodenal paragangliomas.