Systolic and pulse pressure associate with incident knee osteoarthritis: data from the Osteoarthritis Initiative.
Systolic and pulse pressure associate with incident knee osteoarthritis: data from the Osteoarthritis Initiative.
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DOI：
10.1007/s10067-017-3656-z
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发表时间：
2017-09
影响因子：
3.4
通讯作者：
Suarez-Almazor ME
中科院分区：
文献类型：
--
作者：
Lo GH;McAlindon TE;Katz JN;Driban JB;Price LL;Eaton CB;Petersen NJ;Ballantyne CM;Suarez-Almazor ME
我们在一个美国队列中评估了收缩压、舒张压、脉压和降压药治疗与膝骨关节炎发病率的关系。我们在骨关节炎倡议研究中进行了一项纵向研究（2004 - 2010），仅包括基线时无膝骨关节炎的个体。在基线、12个月、24个月和36个月随访时评估收缩压、舒张压和脉压。基线，12个月，24个月，36个月和48个月的膝关节x线片定义骨关节炎，Kellgren和Lawrence分级≥2。我们进行了逻辑回归，调整了年龄、性别、体重指数、非甾体抗炎药的使用、抗高血压药物、糖尿病药物和胆固醇药物的数量。共纳入1930人（6040项观察）。按收缩压四分位数（从最低到最高）划分的影像学骨关节炎年发病率分别为2.1%、3.4%、3.7%和3.7%。相对于最低的四分位数，第2 - 4四分位数的放射学OA的完全调整优势比分别为1.6、1.7和1.6（趋势p = 0.03）。脉压结果相似。与舒张压无关。与未服用任何抗高血压药物的患者相比，服用≥3种抗高血压药物的患者发生OA的几率降低（0.4,0.1-1.0）。在美国的一项队列研究中，较高的收缩压和脉压与膝关节骨性关节炎的发病率增加有关，而使用≥3种降压药物治疗与发病率降低有关。这些发现为研究膝关节骨关节炎的疾病改变提供了一条新的、有前途的途径。
We evaluated the relationship of systolic blood pressure, diastolic blood pressure, pulse pressure, and treatment with antihypertensives with knee osteoarthritis incidence in a United States cohort. We performed a longitudinal study (2004 – 2010) nested within the Osteoarthritis Initiative Study including only individuals without knee osteoarthritis at baseline. Systolic blood pressure, diastolic blood pressure and pulse pressure were assessed at baseline, 12-, 24-, and 36-month visits. Knee radiographs at baseline, 12-, 24-, 36- and 48 month visits defined radiographic osteoarthritis, Kellgren and Lawrence grade ≥ 2. We performed logistic regression, adjusting for age, sex, body mass index, NSAID use, number of antihypertensive medications, diabetic medications, and cholesterol medications. 1930 people (6040 observations) were included. Annual incidence rates of radiographic osteoarthritis by systolic blood pressure quartiles (lowest to highest) were 2.1%, 3.4%, 3.7%, and 3.7%. Fully adjusted odds ratios of incident radiographic OA for the 2nd–4th quartiles were 1.6, 1.7, and 1.6 relative to the lowest quartile (p for trend = 0.03). Pulse pressure results were similar. There was no association with diastolic blood pressure. Compared to those not taking any antihypertensive medications, those taking ≥ 3 had decreased odds (0.4, 0.1–1.0) of developing incident OA. In a United States cohort, higher systolic blood pressure and pulse pressure are associated with increased incidence of radiographic knee osteoarthritis while treatment with ≥ 3 antihypertensive medications was associated with reduced incidence. These findings suggest a new and promising avenue for research on disease modification in knee osteoarthritis.
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影响因子：
7
作者：
Hussain, S. M.;Wang, Y.;Cicuttini, Flavia M.
通讯作者：
Cicuttini, Flavia M.
DOI：
10.1016/j.amjopharm.2010.06.003
发表时间：
2010-06-01
期刊：
AMERICAN JOURNAL OF GERIATRIC PHARMACOTHERAPY
影响因子：
--
作者：
Crentsil, Victor;Ricks, Michelle O.;Fried, Linda P.
通讯作者：
Fried, Linda P.
影响因子：
8.3
作者：
Wallace, Sharon M. L.;Yasmin;Wilkinson, Ian B.
通讯作者：
Wilkinson, Ian B.
影响因子：
--
作者：
POPE, JE;ANDERSON, JJ;FELSON, DT
通讯作者：
FELSON, DT
影响因子：
27.4
作者：
Clockaerts, S.;Van Osch, G. J. V. M.;Bierma-Zeinstra, S. M.
通讯作者：
Bierma-Zeinstra, S. M.