Association of vitamin D receptor gene polymorphisms with metabolic syndrome: a case-control design of population-based cross-sectional study in North China.
Association of vitamin D receptor gene polymorphisms with metabolic syndrome: a case-control design of population-based cross-sectional study in North China.
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DOI：
10.1186/1476-511x-13-129
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发表时间：
2014-08-09
影响因子：
4.5
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Zhao Y;Liao S;He J;Jin Y;Fu H;Chen X;Fan X;Xu H;Liu X;Jin J;Zhang Y
代谢综合征（MS）增加了发生心血管疾病（CVD）和2型糖尿病（T2 DM）的风险。维生素D受体基因（VDR）可能与MS的发生有关，本研究旨在探讨VDR基因多态性与中国北方人群MS的相关性。在2008年至2012年在中国宁夏回族自治区进行的一项横断面研究的基础上，进行了一项病例对照研究，包括391名根据国际糖尿病联合会2005（IDF 2005）MS诊断标准的MS参与者和400名对照。在现场调查中收集了人体测量数据、血压和血液样本。在实验室进行血液生化分析。对VDR基因中的两个单核苷酸多态性（SNPs）BsmI（rs 1544410 A > G）和FokI（rs 2228570 C > T）进行基因分型。MS患者与对照组BsmI基因型分布差异有统计学意义。与基因型B B/bb和等位基因B相比，BB基因型和等位基因B在MS患者中的分布频率明显高于对照组，提示它们是MS的危险因素。此外，BB基因型MS携带者腰围增大，而FokI基因FF型MS携带者BMI降低。本研究提示VDR基因多态性与北方人群MS相关。BsmI基因B等位基因和BB基因型是MS的危险因素。在MS患者中，BsmI基因多态性似乎影响腰围，而FokI基因多态性影响BMI。
Metabolic syndrome (MS) increases a risk of developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The Vitamin D Receptor gene (VDR) may be important for developing MS. The aim of this study is to investigate the correlation between the VDR gene polymorphisms and MS in North China. A case–control study included 391 participants with MS according to the MS diagnostic criteria of International Diabetes Federation 2005 (IDF2005) and 400 controls was conducted on the basis of a cross sectional study which was performed from 2008 to 2012 in Ningxia Hui Autonomous Region, China. Anthropometric data, blood pressure and blood samples were collected in the field investigation. Blood biochemistry analyses were carried out in the laboratory. Two single-nucleotide polymorphisms (SNPs) in the VDR gene, BsmI (rs1544410 A > G) and FokI (rs 2228570 C > T), were genotyped. The difference in the occurrence of genotypes in BsmI between individuals with MS and the control group was significant. Compared with genotype Bb/bb and allele b, genotype BB and allele B showed higher frequencies in MS cases than controls, which suggested they were risk factors. In addition, the genotype BB carriers with MS presented a higher waist circumference, while genotype FF for the FokI polymorphism was correlated with lower BMI in subjects with MS. Our study suggests that the VDR gene polymorphisms appear to be associated with MS in the Northern Chinese population. Allele B and BB genotype for BsmI are risk factors for MS. The BsmI polymorphism seems to influence waist circumference, while the FokI polymorphism influence BMI in subjects with MS.