The brown fat secretome: metabolic functions beyond thermogenesis.
The brown fat secretome: metabolic functions beyond thermogenesis.
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DOI：
10.1016/j.tem.2015.03.002
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Lin JD
中科院分区：
文献类型：
--
作者：
Wang GX;Zhao XY;Lin JD
棕色脂肪在燃料氧化中具有高度活性，并通过解偶联蛋白1（UCP1）介导的产热耗散化学能。棕色脂肪的激活导致能量消耗增加，肥胖减少，血糖和血脂水平降低，从而有助于更好的体内平衡。解偶联呼吸和产热被认为是棕色脂肪组织代谢益处的原因。最近的研究表明，棕色脂肪细胞也分泌局部和全身影响燃料和能量代谢的因子。这篇综述讨论了支持棕色脂肪的产热独立作用的证据，特别是通过其分泌因子的释放，以及它们在生理学和治疗发展中的意义。
Brown fat is highly active in fuel oxidation and dissipates chemical energy through uncoupling protein 1 (UCP1)-mediated heat production. Activation of brown fat leads to increased energy expenditure, reduced adiposity, and lower plasma glucose and lipid levels, thus contributing to better homeostasis. Uncoupled respiration and thermogenesis have been considered to be responsible for the metabolic benefits of brown adipose tissue. Recent studies have demonstrated that brown adipocytes also secrete factors that act locally and systemically to influence fuel and energy metabolism. This review discusses the evidence supporting a thermogenesis-independent role of brown fat, particularly through its release of secreted factors, and their implications in physiology and therapeutic development.