ELECTROPHYSIOLOGIC AND ANTI-ARRHYTHMIC EFFECTS OF NITROGLYCERIN IN MAN
ELECTROPHYSIOLOGIC AND ANTI-ARRHYTHMIC EFFECTS OF NITROGLYCERIN IN MAN
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DOI：
10.1097/00005344-198109000-00001
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发表时间：
1981-01-01
影响因子：
3
通讯作者：
LEIER, CV
中科院分区：
文献类型：
--
作者：
HOELZER, M;SCHAAL, SF;LEIER, CV
在16例患者静脉注射硝酸甘油（0.25和0.50 [mu] g/kg/min）之前和之后，测定了人心脏的电生理特性和心血管处置。在较高剂量下，硝酸甘油显著缩短心房和心室的有效不应期和希氏束-浦肯野传导（HV间期）。除此之外，一般电生理学效应很少;心房传导间期没有改变，尽管有缩短的趋势，但窦房结功能研究（传导和恢复时间）和房室结传导在硝酸甘油治疗后没有显著变化。硝酸甘油表现出抗心律失常特性;心室刺激后心室回声区和心室回声重复性心室反应搏动的数量显著减少。硝酸甘油改善了5例患者中4例持续重复心室反应的趋势，并消除了1例快速心律失常的发展。虽然这项研究没有描述确切的机制，但很明显，硝酸甘油会引起人类心脏电生理特性的一些变化，并且似乎具有（或引起）有益的抗心律失常作用。
The electrophysiologic properties and the arrhythmic disposition of the human heart were determined in 16 patients before and after the intravenous administration of nitroglycerin (0.25 and 0.50 [mu] g/kg/min). At the higher dose, nitroglycerin significantly shortened the atrial and ventricular effective refractory periods and bundle of His-Purkinje conduction (HV interval). Otherwise, a paucity of general electrophysiologic effects was noted; atrial conduction intervals were not altered, and, although a trend toward shortening occurred, the sinus node function studies (conduction and recovery times) and atrioventricular nodal conduction did not change significantly with nitroglycerin. Nitroglycerin demonstrated antiarrhythmic properties; the ventricular echo zone and the number of ventricular echo-repetitive ventricular response beats following ventricular stimulation decreased significantly with nitroglycerin. Nitroglycerin ameliorated the tendency toward sustained repetitive ventricular response in 4 of 5 patients and obliterated the development of this tachyarrhythmia in 1. Although the precise mechanisms were not delineated by this study, it is clear that nitroglycerin causes some change in the electrophysiologic properties of the human heart and that it appears to have (or elicit) beneficial antiarrhythmic effects.