Animal models of chronic inflammatory arthritis.
Animal models of chronic inflammatory arthritis.
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DOI：
10.1097/00003086-199010000-00007
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发表时间：
1990-10
影响因子：
4.2
通讯作者：
D. Magilavy
中科院分区：
文献类型：
--
作者：
D. Magilavy
动物的使用对于研究幼年关节炎的病因、病理生理和治疗是不可或缺的。由于研究儿童的伦理问题、获得组织的困难、儿童慢性关节炎的异质性表现和多变的病程，潜在的研究范围受到严重限制。本文简要综述了慢性炎性关节炎研究中常用的几种动物模型：皮下气袋模型、抗原诱导模型（包括致关节炎感染因子）和自发模型。在自发和抗原诱导的关节炎动物模型中，局部和全身免疫调节异常显然在关节炎的发病机制中起主要作用。通过阐明对这些抗原的免疫反应，以及遗传和环境的作用，可以更好地了解幼年类风湿性关节炎的发病机制。然而，目前这些模型的复杂性妨碍了对人类疾病进行更明确的解释和外推。
The use of animals has been indispensable to the investigation of the etiology, pathophysiology, and treatment of juvenile arthritis. Because of ethical concerns about studying children, the difficulty of obtaining tissue, and the heterogeneous manifestations and protean course of chronic arthritis in childhood, the scope of potential research has been severely limited. This brief review summarizes a few of the animal models most commonly used in chronic inflammatory arthritis research: subcutaneous air pouch, antigen-induced (including arthritogenic infectious agent), and spontaneous models. In the spontaneous and antigen-induced animal models of arthritis, local and systemic immunoregulatory abnormalities clearly play a major role in the pathogenesis of arthritis. By elucidating the immune response to those antigens, as well as the role of genetics and environment, the pathogenesis of juvenile rheumatoid arthritis may be better understood. At the present time, however, the complexity of these models precludes more definitive interpretation and extrapolation to human diseases.