Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument
Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument
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DOI：
10.1007/s10803-010-1065-0
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发表时间：
2011-04-01
影响因子：
3.9
通讯作者：
Matsuda, Tsuyoshi
中科院分区：
文献类型：
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作者：
Harada, Masafumi;Taki, Masako M.;Matsuda, Tsuyoshi
用3T-MRI对12例孤独症患者和10例正常对照的神经递质相关氨基酸和GABA能/谷氨酸能系统进行了测定。所有测量在额叶(FL)和豆状核(LN)中进行，使用n-乙酰天冬氨酸(NAA)和谷氨酸(Glu)的常规序列，以及GABA的巨型编辑方法。与正常对照组相比，孤独症患者FL的GABA水平和[GABA]/[NAA]值显著降低(p<；0.01)，而LN的GABA水平和[GABA]/[NAA]值无明显变化。FL中的[GABA]/[Glu]比值也显著低于正常对照组(p<；0.05)，提示GABA与Glu之间的调节可能存在异常。
Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu.