Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment
Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment
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DOI：
10.1111/j.1399-302x.2007.00426.x
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发表时间：
2008-08-01
影响因子：
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通讯作者：
Amano, A.
中科院分区：
文献类型：
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作者：
Makiura, N.;Ojima, M.;Amano, A.
简介：本研究的目的是评估2型糖尿病患者牙周治疗后血清血糖水平与龈下微生物谱改变之间的关系。我们研究了30例接受全口龈下清创术的2型糖尿病牙周炎患者，通过使用聚合酶链反应方法分析其基线和不同时间的龈下微生物谱，治疗后12个月。同时，记录探袋深度、探袋出血和代谢参数，包括糖化血红蛋白A1c（HbA1c）、血糖水平、C反应蛋白、总胆固醇、甘油三酯、高密度和低密度脂蛋白胆固醇。治疗后牙周状况明显改善，牙周细菌的出现率，包括牙龈卟啉单胞菌，Tannerella asthensis、齿垢密螺旋体和中间普雷沃菌也减少。有趣的是，牙周治疗后HbA1c值升高的受试者中检出牙龈卟啉单胞菌的频率高于HbA1c值降低的受试者。此外，牙龈卟啉单胞菌与II型菌毛只检测到HbA1c增加的科目，而改善HbA1c值只观察到在没有II型clons.Conclusions：这些结果表明，糖尿病的血糖水平的影响持久性牙龈卟啉单胞菌，尤其是与II型菌毛，在牙周袋克隆。
Introduction: The aim of this study was to assess the relationship between serum glycemic levels and subgingival microbial profile alteration following periodontal treatment in patients with type 2 diabetes mellitus.Methods: We studied 30 periodontitis patients with type 2 diabetes mellitus who received full-mouth subgingival debridement by analyzing their subgingival microbial profiles using a polymerase chain reaction method at baseline and various time-points for 12 months following treatment. Concurrently, probing pocket depth, bleeding on probing, and metabolic parameters, including glycated hemoglobin A1c (HbA1c), blood sugar level, C-reactive proteins, total cholesterol, triglyceride, and high-density and low-density lipoprotein cholesterol, were recorded.Results: Periodontal conditions were significantly improved after treatment, and the occurrence rates of periodontal bacterial species, including Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, and Prevotella intermedia, were also reduced. Interestingly, P. gingivalis was detected more frequently in subjects with increased HbA1c values after periodontal treatment than in those patients with decreased HbA1c values. Furthermore, P. gingivalis with type II fimbriae was detected only in HbA1c-increased subjects, while improvements in HbA1c values were observed only in subjects without type II clones.Conclusions: These results suggest that glycemic level in diabetes is affected by the persistence of P. gingivalis, especially clones with type II fimbriae, in periodontal pockets.