SERUM 25-HYDROXYVITAMIN-D AND COLON CANCER - 8-YEAR PROSPECTIVE-STUDY
SERUM 25-HYDROXYVITAMIN-D AND COLON CANCER - 8-YEAR PROSPECTIVE-STUDY
复制标题
DOI：
10.1016/s0140-6736(89)91789-3
复制
发表时间：
1989-11-18
期刊：
影响因子：
168.9
通讯作者：
GORHAM, ED
中科院分区：
文献类型：
--
作者：
GARLAND, CF;COMSTOCK, GW;GORHAM, ED
1974年在美国马里兰州的华盛顿县采集了25620名志愿者的血样，用于研究血清25-羟维生素D（25-OHD）与结肠癌发病风险的关系。1975年8月至1983年1月间确诊的34例结肠癌患者与67例对照组按年龄、种族、性别和采血月份配对。结肠癌的风险在血清25-OHD的第三个五分位数（27-32 ng/ml）中降低了75%，在第四个五分位数（33-41 ng/ml）中降低了80%。在血清25-OHD浓度为20 ng/ml或更高的人群中，患结肠癌的风险降低了三倍。结果与血清25-OHD对结肠癌的保护作用一致。
Blood samples taken in 1974 in Washington County, Maryland, [USA] from 25 620 volunteers were used to investigate the relation of serum 25-hydroxyvitamin D (25-OHD) with subsequent risk of getting colon cancer. 34 cases of colon cancer diagnosed between August, 1975, and January, 1983, were matched to 67 controls by age, race, sex, and month blood was taken. Risk of colon cancer was reduced by 75% in the third quintile (27-32 ng/ml) and by 80% in the fourth quintile (33-41 ng/ml) of serum 25-OHD. Risk of getting colon cancer decreased three-fold in people with a serum 25-OHD concentration of 20 ng/ml or more. The results are consistent with a protective effect of serum 25-OHD on colon cancer.