Electrochemiluminescence and voltammetry of tris(2,2′-bipyridine)ruthenium (II) with amphetamine-type stimulants as coreactants: an application to the discrimination of methamphetamine
Electrochemiluminescence and voltammetry of tris(2,2′-bipyridine)ruthenium (II) with amphetamine-type stimulants as coreactants: an application to the discrimination of methamphetamine
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DOI：
10.1007/s11419-017-0388-3
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发表时间：
2017
影响因子：
2.2
通讯作者：
F. Takahashi;Saki Nitta;Ryo Shimizu;Jiye Jin
中科院分区：
文献类型：
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作者：
F. Takahashi;Saki Nitta;Ryo Shimizu;Jiye Jin
目的建立一种电化学发光（ECL）伏安法检测兴奋剂的新方法，并用于法医样品中兴奋剂的检测。方法以甲基苯丙胺（MA）、苯丙胺（AM）、二甲基苯丙胺（DMA）和甲氧那明（MP）等苯丙胺类兴奋剂为共反应物，在[Ru（bpy）3]2+存在下，用电化学方法检测了不同浓度的苯丙胺类兴奋剂，并与其他兴奋剂进行了比较。结果MP在+1.1 V和+1.4 V处有两个电化学发光峰，而MA和DMA在+1.1 V处有一个电化学发光峰，AM无电化学发光响应。提出了不同的反应机理来理解[Ru（bpy）3]2+/ATS体系产生电致发光。由于这些ATS在玻碳电极上的伏安响应也是不同的，因此可以基于特征ECL和循环伏安信号在没有分离过程的情况下检测MA。将电化学发光法与伏安法相结合，建立了一种简单、快速的MA检测方法，并应用于人尿样中MA的检测，具有较高的灵敏度。
PurposeWe have tried to establish an electrochemical detection method for screening of the stimulants in the forensic samples using electrochemiluminescence (ECL) and voltammetric techniques.MethodsAmphetamine-type stimulants (ATSs), such as methamphetamine (MA), amphetamine (AM), dimethylamphetamine (DMA), and methoxyphenamine (MP) have been studied as coreactants in the [Ru(bpy)3]2+(bpy = 2,2′-bipyridine) ECL system.ResultsThere were two specific ECL peaks located at + 1.1 and + 1.4 V for MP, whereas there was only one ECL peak at + 1.1 V for MA and DMA, and no ECL response for AM. Different reaction mechanisms were proposed to understand the generation of ECL by the [Ru(bpy)3]2+/ATS system. Because the voltammetric responses of these ATSs at a glassy carbon electrode were also different, it was possible to detect MA without a separation process based on the characteristic ECL and cyclic voltammetric signals. By a combination of ECL and voltammetric measurements, a simple and rapid screening method for MA could be proposed, and was applied in the determination of MA in human urine samples with sufficient sensitivity.ConclusionsThe present electrochemical approach seems to provide a new way for primary screening of MA in forensic application.