Urinary uric acid and antioxidant capacity in children and adults with Down syndrome
Urinary uric acid and antioxidant capacity in children and adults with Down syndrome
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DOI：
10.1016/j.clinbiochem.2009.09.017
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发表时间：
2010-02-01
影响因子：
2.8
通讯作者：
Casado, Angela
中科院分区：
文献类型：
--
作者：
Campos, Carlos;Guzman, Rodrigo;Casado, Angela
目的：为了评估尿酸（UA）和总抗氧化能力（TAC）与UA的相对贡献（TAC（-UA））在儿童和成人唐氏综合征（DS），并证明TAC的临床用途。设计和方法：尿液样本从32个个体与DS和29个对照组。设立了两个年龄组（儿童和成人）。结果：DS患儿UA/Cr、TAC/Cr明显高于对照组，而成人组TAC（-UA）/Cr明显低于对照组（P
Objectives: To evaluate the urinary levels of uric acid (UA) and total antioxidant capacity (TAC) with and without UA relative contribution (TAC(-UA)) in children and adults with Down syndrome (DS) and to prove the clinical use of TAC.Design and methods: Urine samples were obtained from 32 individuals with DS and 29 controls. Two age groups were established (children and adults). Spectrophotometric methods were used for biochemical determinations.Results: Children with DS had significantly higher UA/Cr and TAC/Cr levels than controls, whereas levels of TAC(-UA)/Cr were lower in adults with DS than in controls (P