Seasonal Variation and Trend of Intraocular Pressure Decrease Over a 20-Year Period in Normal-Tension Glaucoma Patients
Seasonal Variation and Trend of Intraocular Pressure Decrease Over a 20-Year Period in Normal-Tension Glaucoma Patients
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DOI：
10.1016/j.ajo.2021.10.001
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发表时间：
2022-02-01
影响因子：
4.2
通讯作者：
Kinoshita, Shigeru
中科院分区：
文献类型：
--
作者：
Ikeda, Yoko;Mori, Kazuhiko;Kinoshita, Shigeru
目的：通过对京都国立医科大学青光眼病历数据库的回顾分析，探讨正常眼压性青光眼患者眼压在20年间的季节性变化趋势。设计：回顾性队列研究。方法：从1774例正常眼压性青光眼患者的病历中回顾提取数据点(n=49,007)，其中男性665例，女性1109例；平均+/-SD年龄59.8±14.4岁；平均+/-SD观察期5.6±4.4年。我们首先根据1997年1月至2016年12月每个月的所有可用数据计算了平均顶峰。然后将数据分为5组，每组连续4年(1997-2000、2001-2004、2005-2008、2009-2012和2013-2016)，并计算组内每个月的平均顶部。结果：20年间TOP呈持续下降趋势(P&t；.001)，且具有明显的季节变化。年平均+/-SD峰值在最老组(1997-2000)最高(13.9+/-2.7 mm Hg)，随后各组逐渐下降，最后在最近一组(2013-2016)最低(12.3+/-2.7 mm Hg)(P<；.001)，且均伴有明显的季节变化(P<；结论：基于京都地方医科大学青光眼登记处真实世界的纵向数据，我们的发现显示，在20年的研究期间，正常眼压性青光眼患者的TOP持续下降，并有明显的季节性变化。(C)2021 Elsevier Inc.保留所有权利。
PURPOSE: To investigate the trend of seasonal variation of intraocular pressure (TOP) in patients with normal-tension glaucoma over a 20-year period by retrospectively analyzing the Kyoto Prefectural University of Medicine Glaucoma Registry database as real-world data.DESIGN: Retrospective cohort study.METHODS: Data points (n = 49,007) were extracted retrospectively from the medical records of 1774 patients with normal-tension glaucoma (665 male patients and 1109 female patients; mean +/- SD age was 59.8 +/- 14.4 years; and mean +/- SD observation period was 5.6 +/- 4.4 years) seen over the 20-year period. We first calculated the mean TOP from all available data of each month from January 1997 through December 2016. The data were then categorized into 5 groups of 4 consecutive years each (1997-2000, 2001-2004, 2005-2008, 2009-2012, and 2013-2016) and the mean TOP of each month within the group was calculated. Seasonal variations of TOP over the 20-year study period and in the 5 consecutive groups were then investigated via nonlinear multiple regression analysis.RESULTS: A continuous decrease of TOP was detected throughout the 20-year period (P < .001), with distinct seasonal variation. The annual mean +/- SD TOP was highest (13.9 +/- 2.7 mm Hg) in the oldest group (1997-2000), with a gradual decrease in each subsequent group, finally becoming lowest (12.3 +/- 2.7 mm Hg) in the most recent group (2013-2016) (P < .001), and all of them were accompanied by distinct seasonal variation (P < .001).CONCLUSIONS: Based on the Kyoto Prefectural University of Medicine Glaucoma Registry real-world longitudinal data, our findings revealed a continuous decrease and distinct seasonal variation of TOP in patients with normal-tension glaucoma throughout the 20-year study period. (C) 2021 Elsevier Inc. All rights reserved.