Serum Surfactant Protein D is Associated with Atherosclerosis of the Carotid Artery in Patients on Maintenance Hemodialysis
Serum Surfactant Protein D is Associated with Atherosclerosis of the Carotid Artery in Patients on Maintenance Hemodialysis
复制标题
维持性血液透析患者血清表面活性蛋白 D 与颈动脉粥样硬化相关
DOI：
10.7754/clin.lab.2015.150536
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发表时间：
2016-01-01
影响因子：
0.7
通讯作者：
Yuan, Hai
中科院分区：
文献类型：
--
作者：
Hu, Fengqi;Zhong, Qinglian;Yuan, Hai
背景：表面活性蛋白-D(SP-D)是一种炎症调节剂，与慢性肾脏疾病患者的心血管疾病相关死亡率、估计的肾小球滤过率和主要不良心脏事件有关。本研究旨在探讨维持性血液透析患者血浆SP-D水平与动脉粥样硬化的关系。采用高分辨率超声测量颈动脉内膜中层厚度(CA-IMT)，多层螺旋CT测定冠状动脉钙化(CAC)积分。结果：长期血液透析患者血清SP-D水平平均为192.9+/-89.6pg/mL(范围89-537pg/mL)。血清SP-D水平与CA-IMT(r=0.497，p<；0.0001)和重度CAC(r=0.352，p=0.02)呈正相关，经多因素相关分析后仍维持相关。结论：长期血液透析患者SP-D水平与颈动脉CA-IMT、CAC呈正相关。因此，SP-D可能是血液透析患者动脉粥样硬化的一种新的标志物。
Background: Surfactant protein-D (SP-D) is an inflammatory modulator that has been associated with cardiovascular disease-related mortality, estimated glomerular filtration rate, and major adverse cardiac events in patients with chronic kidney disease. The aim of this study was to investigate the link between SP-D level and atherosclerosis in patients on hemodialysis.Methods: A total of 116 patients undergoing maintenance hemodialysis were recruited to this cross-sectional study. As a marker of atherosclerosis, the carotid artery intima-media thickness (CA-IMT) was measured by high-resolution ultrasonography, and the coronary artery calcification (CAC) score was determined by multislice computed tomography. Serum SP-D levels were measured by a commercial enzyme-linked immunosorbent assay kit.Results: In patients on long-term hemodialysis, the mean serum SP-D level was 192.9 +/- 89.6 pg/mL (range: 89 - 537 pg/mL). The serum SP-D level exhibited positive correlations with CA-IMT (r = 0.497, p < 0.0001) and severe CAC (r = 0.352, p = 0.02), which persisted after multivariate adjustment.Conclusions: The SP-D level showed positive correlations with carotid CA-IMT and CAC in patients on long-term hemodialysis. Therefore, SP-D may be a novel marker of atherosclerosis in patients with hemodialysis.