Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs.
Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs.
复制标题
慢性运动可增强清醒犬心外膜冠状动脉内皮介导的扩张。
DOI：
10.1161/01.res.73.5.829
复制
发表时间：
1993
影响因子：
20.1
通讯作者：
Hintze,TH
中科院分区：
文献类型：
--
作者：
Wang,J;Wolin,MS;Hintze,TH
内皮源性松弛因子(EDRF)/一氧化氮(NO)在急性运动时冠状动脉左回旋支扩张中是否起作用，以及慢性运动训练后左回旋支血管内皮细胞介导的扩张是否发生改变，目前尚不清楚。对9只犬进行了系统血流动力学、冠状动脉左回旋支直径和血流量的慢性测量。急性平板运动(10.9 km/h)使冠状动脉回旋支扩张4.33±-0.84%，冠脉血流量增加32+/-5.2mL/min。静脉注射硝基-L-精氨酸后，冠状动脉回旋支扩张转为血管收缩(-4.13+/-1.58%)，而冠脉血流量增加(24+/-3.6mL/min)无明显变化。慢性运动训练(每天2小时，10.9公里/小时，持续7天)增强了乙酰胆碱诱导的大冠状动脉扩张和反应性扩张(冠状动脉短暂闭塞后的反应性扩张)(P<；0.05)，而冠状动脉血流反应没有改变。这些增强的乙酰胆碱引起的冠状动脉回旋和反应性扩张是由于被硝基-L-精氨酸消除后释放更多的EDRF/NO所致。因此，在回旋支冠状动脉中，EDRF/NO依赖的扩张在7天的运动训练后得到增强。这可能代表了人们认为长期锻炼会导致心血管“健康”的机制。
Whether endothelium-derived relaxing factor (EDRF)/nitric oxide (NO) plays a role in the dilation of the left circumflex coronary artery during acute exercise and whether endothelium-mediated dilation of this artery is altered after chronic exercise training have not been determined previously. Nine dogs were chronically instrumented for measurements of systemic hemodynamics, left circumflex coronary artery diameter, and blood flow. Acute treadmill exercise (10.9 km/h) caused dilation of the circumflex coronary artery by 4.33 +/- 0.84% and an increase in coronary blood flow by 32 +/- 5.2 mL/min. After the administration of intravenous nitro-L-arginine, the dilation of the circumflex coronary artery was converted to vasoconstriction (-4.13 +/- 1.58%), whereas the increase in coronary blood flow was not altered (24 +/- 3.6 mL/min). Chronic exercise training (2 hours each day at a speed of 10.9 km/h for 7 days) enhanced acetylcholine-induced dilation and reactive dilation (following release of a brief coronary artery occlusion) of the large coronary artery (P < .05), whereas the coronary blood flow responses were not changed. These enhanced acetylcholine-induced and reactive dilations of the circumflex coronary artery were due to a greater release of EDRF/NO since they were eliminated by nitro-L-arginine. Thus, in the circumflex coronary artery, EDRF/NO-dependent dilation was enhanced after 7 days of exercise training. This may represent the mechanism responsible for the perception that chronic exercise induces cardiovascular "well being."