RISK-FACTORS FOR NIDDM IN WHITE-POPULATION - PARIS PROSPECTIVE-STUDY
RISK-FACTORS FOR NIDDM IN WHITE-POPULATION - PARIS PROSPECTIVE-STUDY
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DOI：
10.2337/diabetes.40.7.796
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发表时间：
1991-07-01
期刊：
影响因子：
7.7
通讯作者：
ESCHWEGE, E
中科院分区：
文献类型：
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作者：
CHARLES, MA;FONTBONNE, A;ESCHWEGE, E
对5042名中年白色男性进行了3年的非胰岛素依赖型糖尿病（NIDDM）危险因素的评估。 受试者是巴黎前瞻性研究I的参与者。 63例受试者在随访期间发生糖尿病。 在疾病发生前几年的血糖浓度是一个主要的危险因素。 葡萄糖耐量正常但空腹血糖升高的受试者发生NIDDM的风险与根据2小时后血糖分类为葡萄糖耐量受损的受试者相似。 在多元Logistic回归分析中，高空腹血浆胰岛素浓度和低2小时血浆胰岛素浓度后，葡萄糖负荷与高体重指数是独立的预测转换为NIDDM的糖耐量受损。 此前，这一结果仅在瑙鲁人、皮马印第安人和日本人中发现。 这第一次证明在白色人群中，高空腹和低2小时胰岛素浓度可预测从糖耐量受损转化为NIDDM。
Risk factors for non-insulin-dependent diabetes mellitus (NIDDM) were assessed in a population of 5042 middle-aged white men, initially nondiabetic, who were followed 3 yr. The subjects were participants in the Paris Prospective Study I. Sixty-three subjects developed diabetes during the follow-up. Plasma glucose concentration in the years before the occurrence of the disease was a major risk factor. Subjects with normal glucose tolerance but elevated fasting plasma glucose exhibited a similar risk of developing NIDDM as did subjects classified as having impaired glucose tolerance on the basis of 2-h postload glucose. In a multiple logistic regression, a high fasting plasma insulin concentration and a low 2-h plasma insulin concentration after a glucose load in association with a high body mass index were independent predictors of conversion to NIDDM from impaired glucose tolerance. Previously, this result had been found only in Nauruans, Pima Indians, and Japanese. This demonstrates for the first time in a white population that a high fasting and low 2-h insulin concentration is predictive of conversion to NIDDM from impaired glucose tolerance.