Synthesis of Novel Aryl and Heteroaryl Acyl Sulfonimidamides via Pd-Catalyzed Carbonylation Using a Nongaseous Precursor
Synthesis of Novel Aryl and Heteroaryl Acyl Sulfonimidamides via Pd-Catalyzed Carbonylation Using a Nongaseous Precursor
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DOI：
10.1021/ol400049m
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发表时间：
2013-03-01
期刊：
影响因子：
5.2
通讯作者：
Arvidsson, Per I.
中科院分区：
文献类型：
--
作者：
Borhade, Sanjay R.;Sandstrom, Anja;Arvidsson, Per I.
通过开发一种新的钯催化羰基化方法制备了芳基和杂芳基酰基磺酰亚胺酰胺。这种新的方法，采用磺酰亚胺酰胺作为亲核试剂和CO气体从固体Mo（CO）（6）在一个密封的双室系统中的异位释放，产生了广泛的氨基甲酸酯保护的酰基磺酰亚胺酰胺在良好至优异的产率。
Hitherto unexplored aryl and heteroaryl acyl sulfonimidamides have been prepared through the development of a new Pd-catalyzed carbonylation protocol. This novel methodology, employing sulfonimidamides as nucleophiles and CO gas ex situ released from solid Mo(CO)(6) in a sealed two-chamber system, yields a wide range of carbamate protected acyl sulfonimidamides in good to excellent yields.