ANGIOGENESIS MEDIATED BY SOLUBLE FORMS OF E-SELECTIN AND VASCULAR CELL-ADHESION MOLECULE-1
ANGIOGENESIS MEDIATED BY SOLUBLE FORMS OF E-SELECTIN AND VASCULAR CELL-ADHESION MOLECULE-1
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DOI：
10.1038/376517a0
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发表时间：
1995-08-10
期刊：
影响因子：
64.8
通讯作者：
POLVERINI, PJ
中科院分区：
文献类型：
--
作者：
KOCH, AE;HALLORAN, MM;POLVERINI, PJ
内皮粘附分子促进白细胞进入发炎组织。这反过来会促进新血管形成，这是类风湿性关节炎进展、肿瘤生长和伤口修复的核心过程(1)。在这里，我们检验了可溶性内皮粘附分子促进血管生成的假设(2-4)，人重组可溶性E-选择素和可溶性血管细胞粘附分子-1在体外诱导人内皮细胞趋化，并在大鼠角膜中产生血管生成。可溶性E-选择素部分通过唾液酸Lewis-X依赖性机制作用于内皮细胞，而可溶性血管细胞粘附分子-1部分通过极晚期抗原(VLA)-4依赖性机制作用于内皮细胞。类风湿滑液对内皮细胞的趋化活性及其血管生成活性被可溶性E-选择素或可溶性血管细胞粘附分子-1的抗体阻断。这些结果表明可溶性内皮粘附分子作为血管生成介质的新功能。
ENDOTHELIAL adhesion molecules facilitate the entry of leukocytes into inflamed tissues. This in turn promotes neovascularization, a process central to the progression of rheumatoid arthritis, tumour growth and wound repair(1). Here we test the hypothesis that soluble endothelial adhesion molecules promote angiogenesis(2-4), Human recombinant soluble E-selectin and soluble vascular cell adhesion molecule-1 induced chemotaxis of human endothelial cells in vitro and were angiogenic in rat cornea. Soluble E-selectin acted on endothelial cells in part through a sialyl Lewis-X-dependent mechanism, while soluble vascular cell adhesion molecule-1 acted on endothelial cells in part through a very late antigen (VLA)-4 dependent mechanism, The chemotactic activity of rheumatoid synovial fluid for endothelial cells, and also its angiogenic activity, were blocked by antibodies to either soluble E-selectin or soluble vascular cell adhesion molecule-1. These results suggest a novel function for soluble endothelial adhesion molecules as mediators of angiogenesis.