Chlamydia A in the female genital tract.
Chlamydia A in the female genital tract.
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女性生殖道中的衣原体 A。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
Hilton
中科院分区：
文献类型：
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作者：
A. L. Hiltont;S. Richmond;J. D. Milnet;F. Hindleyt;S. Clarke;Jones;Smith Collier;Al;Dunlop;Al;Garland;Vaughan;Oriel;Nicol Reeve;Richmond;Hilton
衣原体A的第一个生殖道分离株是通过在受精卵的卵黄囊中生长，从患有TRIC眼炎的婴儿的父母那里获得的（Jones，Collier和Smith，1959; Jones，Al-Hussaini和Dunlop，1964）。注意到这些婴儿的父亲经常患有非淋菌性尿道炎（NGU），母亲经常表现出子宫颈的变化。从9名NGU男性患者中的2名中分离出衣原体，证实了这些微生物与非特异性生殖器感染有关（Dunlop、Al-Hussaini、加兰、Treharne、哈珀和Jones，1965年）。这些早期的观察结果已经得到证实，并在开发用于分离衣原体A的辐照麦考伊细胞培养物后得到了扩展。利用这种技术，已经确定可以从约40%的NGU患者的尿道中分离出衣原体（Dunlop、Vaughan-Jackson、Darougar和Jones，1972年; Oriel、Reeve、Powis、米勒和Nicol，1972年;里士满，希尔顿，和克拉克，1972年），他们只是很少孤立于同样滥交的男子没有尿道炎（Oriel等，1972年;里士满等，1972年）。然而，在男性淋病患者中也显示出类似的分离率（G）（里士满等，1972），这就对衣原体感染是否是NGU的初始病因提出了疑问，并提出了任何原因的尿道炎都可能激活男性尿道中存在的但静止的衣原体感染。这种激活的感染似乎是致病性的，因为衣原体阳性的G患者比衣原体阴性的G患者更容易发生淋球菌后尿道炎（PGU），并且由于长期未经治疗的尿道感染的NGU男性中衣原体的分离率很低，
The first genital tract isolates of Chlamydia A were obtained from parents of babies suffering from TRIC ophthalmia neonatorum, by growth in the yolk sac of fertile eggs (Jones, Collier, and Smith, 1959; Jones, Al-Hussaini, and Dunlop, 1964). It was noted that the fathers of these babies were frequently suffering from non-gonococcal urethritis (NGU) and that the mothers often showed changes in the cervix. The isolation of Chlamydia from two of nine unselected males suffering from NGU confirmed the association of these organisms with non-specific genital infection (Dunlop, Al-Hussaini, Garland, Treharne, Harper, and Jones, 1965). These early observations have been confirmed and extended since the development of irradiated McCoy cell cultures for the isolation of Chlamydia A. With this technique, it has been established that Chlamydia can be isolated from the urethra of about 40 per cent. of men with NGU (Dunlop, Vaughan-Jackson, Darougar, and Jones, 1972; Oriel, Reeve, Powis, Miller, and Nicol, 1972; Richmond, Hilton, and Clarke, 1972) and that they are only rarely isolated from equally promiscuous men without urethritis (Oriel and others, 1972; Richmond and others, 1972). However, a similar isolation rate was shown in men suffering from gonorrhoea (G) (Richmond and others, 1972) which threw doubt on whether a chlamydial infection was the initial cause of NGU, and raised the possibility that urethritis of any cause activated an existing but quiescent chlamydial infection in the male urethra. This activated infection appeared to be pathogenic since Chlamydia-positive patients with G were much more prone to develop post-gonococcal urethritis (PGU) than Chlamydia-negative G patients, and since the isolation rate of Chlamydia in men with NGU who had a long-standing untreated urethral