Investigating individual differences in opioid-taking and opioid-seeking behavior in male rats
Investigating individual differences in opioid-taking and opioid-seeking behavior in male rats
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DOI：
10.1007/s00213-021-06023-2
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发表时间：
2022-01-04
影响因子：
3.4
通讯作者：
Flagel, Shelly B.
中科院分区：
文献类型：
--
作者：
Chang, Stephen E.;Krueger, Lauren D.;Flagel, Shelly B.
基本原理了解的行为和神经生物学因素，使一些人比其他人更容易受到阿片类药物成瘾将是至关重要的，在打击阿片类药物crisis.Objective本研究的目的是要确定是否与增加的可能性采取和寻求可卡因的行为特征是相同的特征，使一个更容易受到阿片类药物服用和阿片类药物寻求行为。使用两种动物模型：高反应者（HR）/低反应者（LR）和符号追踪者（ST）/目标追踪者（GT）模型，研究了瑞芬太尼自我给药和随后线索诱导的瑞芬太尼寻求行为恢复的个体差异。相对于LR大鼠，HR大鼠表现出增加的新奇诱导的运动或“感觉寻求”行为，并且更有可能获得可卡因服用行为，并且以更快的速度进行。相对于GT大鼠，ST大鼠属性更大的激励动机价值奖励线索，更有可能表现出恢复可卡因寻求behaviors.Results在以前的工作使用可卡因相比，我们没有观察到个体差异方面的收购瑞芬太尼自我管理或线索诱导恢复瑞芬太尼寻求行为的背景下，无论是HR/LR或ST/GT模型。因此，无论是感觉寻求的特质，也没有倾向于属性奖励动机价值奖励线索预测remifentanil服用或remifentanil seeking behavior.Conclusions这些研究结果表明，不同的特质可能会赋予阿片类药物与可卡因服用行为的启动，以及阿片类药物与可卡因寻求复发的倾向。需要进一步的研究来确定哪些神经行为结构赋予阿片类药物使用和复发的责任。
Rationale Understanding the behavioral and neurobiological factors that render some individuals more susceptible than others to opioid addiction will be critical in combatting the opioid crisis.Objective The purpose of the current study was to determine if behavioral traits associated with an increased likelihood to take and seek cocaine are the same traits that render one more susceptible to opioid-taking and opioid-seeking behavior. Individual differences in the acquisition of remifentanil self-administration and subsequent cue-induced reinstatement of remifentanil-seeking behavior were investigated using two animal models: the high-responder (HR)/low-responder (LR) and sign-tracker (ST)/goal-tracker (GT) models. Relative to LR rats, HR rats show increased novelty-induced locomotion or "sensation-seeking" behavior, and are more likely to acquire cocaine-taking behavior and do so at a faster rate. Relative to GT rats, ST rats attribute greater incentive motivational value to reward cues and are more likely to exhibit reinstatement of cocaine-seeking behavior.Results In contrast to previous work using cocaine, we did not observe individual differences with respect to the acquisition of remifentanil self-administration- or cue-induced reinstatement of remifentanil-seeking behavior within the context of either the HR/LR or ST/GT model. Thus, neither the sensation-seeking trait nor the propensity to attribute incentive motivational value to reward cues predicts remifentanil-taking or remifentanil-seeking behavior.Conclusions These findings suggest that different traits may confer the initiation of opioid- vs. cocaine-taking behavior, and the propensity to relapse to opioid- vs. cocaine-seeking. Additional studies are needed to identify which neurobehavioral constructs confer liability to opioid use and relapse.