LONG-TERM EFFECTS OF MODEST WEIGHT-LOSS IN TYPE-II DIABETIC-PATIENTS
LONG-TERM EFFECTS OF MODEST WEIGHT-LOSS IN TYPE-II DIABETIC-PATIENTS
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DOI：
10.1001/archinte.147.10.1749
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发表时间：
1987-10-01
影响因子：
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通讯作者：
BECKER, D
中科院分区：
文献类型：
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作者：
WING, RR;KOESKE, R;BECKER, D
由于大多数患有II型糖尿病的肥胖患者无法达到理想的体重，这项研究探讨了更适度的体重减轻是否会提供长期的益处。II型糖尿病患者（N = 114）接受行为体重控制计划治疗，并随访一年。体重减轻与治疗后（r = 0.55）和1年（r = 0.51）糖化血红蛋白值的改善显著相关。体重减轻超过6.9 kg或体重减轻超过5%的患者在1年时糖化血红蛋白值有显著改善，而体重减轻较少的患者变化不显著，体重增加的患者有显著恶化。因此，适度的减肥可以对血糖控制产生长期影响。然而，对于给定的体重减轻，血糖控制的改善最初大于一年，这表明除了体重减轻之外，能量限制可能有助于最初的改善。 无论是超重百分比还是糖尿病治疗都不会影响体重减轻。
Since most obese patients with type II diabetes are unable to achieve ideal body weight, this study examined whether more modest weight losses would provide a long-term benefit. Type II diabetic patients (N = 114) were treated in a behavioral weight control program and followed up for one year. Weight loss was significantly correlated with improvements in glycosylated hemoglobin values at posttreatment (r = .55) and one year (r = .51). Patients who lost more than 6.9 kg or had more than 5% reduction in body weight had significant improvements in glycosylated hemoglobin values at one year, while patients losing less weight had nonsignificant changes and those gaining weight had significant worsening. Thus, modest weight loss can have a long-term impact on glycemic control. However, the improvement in glycemic control for a given weight loss was greater initially than at one year, suggesting that energy restriction, in addition to weight loss, may contribute to initial improvement. Neither percent overweight nor diabetes treatment affected weight loss.