Chemical Constituents of Plants from the Genus Brucea
Chemical Constituents of Plants from the Genus Brucea
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DOI：
10.1002/cbdv.200700409
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Shen, Yun-Heng
中科院分区：
文献类型：
--
作者：
Liu, Jian-Hua;Jin, Hui-Zi;Shen, Yun-Heng
1. 介绍。布氏属约有6种，主要分布于东半球热带地区。bruucea mollis和B. javanica是中国仅有的两种，因其抗肿瘤和抗疟疾活性而被用作传统中草药。绿色草本植物mollis分布在中国西南部（云南和广州）。药用植物爪哇具有更多的生物活性。这种植物被称为雅丹子，分布在中国南方（主要是广西和广东），具有抗肿瘤、抗疟疾和抗胃溃疡的活性[1-3]。由于布鲁属植物具有多方面的活性，其化学成分近年来受到广泛的关注。对布鲁士属的广泛研究已经鉴定出许多化合物，如黑草内酯、生物碱、三萜和类黄酮。本文综述了近几十年来从该属植物中分离到的化合物的研究进展，并对其生物活性进行了综述。
1. Introduction.–Brucea is a genus with ca. six species mainly found in tropical eastern hemisphere areas. Brucea mollis and B. javanica, the only two species in China, are used as traditional herbal medicines because of their antitumor and antimalaria activities [1]. The green herbal medicinal plant B. mollis is distributed in southwestern China (Yunnan and Guangzhou Provinces). The herbal medicinal plant B. javanica exhibits more biological activities. This plant, called Yadanzi, distributed in the south of China (mainly Guangxi and Guangdong Provinces), shows antitumor, antimalaria, and antigastric-ulcer activities [1–3]. Recently, much attention has been paid to the Brucea genus and its chemical constituents because of the multifaceted activities. Extensive studies of the genus Brucea have led to the identification of many compounds, such as nigakilactones, alkaloids, triterpenoids, and flavonoids. In this review, we summarize the phytochemical progress and list the compounds isolated from the genus Brucea over the past decades, also considering the biological activities.