Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.
Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia.
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DOI：
10.7554/elife.63430
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发表时间：
2020-12-17
期刊：
影响因子：
7.7
通讯作者：
Massey RC
中科院分区：
文献类型：
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作者：
Gregorova M;Morse D;Brignoli T;Steventon J;Hamilton F;Albur M;Arnold D;Thomas M;Halliday A;Baum H;Rice C;Avison MB;Davidson AD;Santopaolo M;Oliver E;Goenka A;Finn A;Wooldridge L;Amulic B;Boyton RJ;Altmann DM;Butler DK;McMurray C;Stockton J;Nicholls S;Cooper C;Loman N;Cox MJ;Rivino L;Massey RC
在这里，我们描述了一个新冠肺炎患者谁发展成反复呼吸机相关肺炎铜绿假单胞菌引起的治疗获得了越来越多的抗菌素耐药性(Amr)的反应。元基因组分析显示了AMR基因，而免疫学分析显示T细胞激活水平大量并不断上升。这些都是SARS-CoV-2和铜绿假单胞菌特异的，旁观者被激活，这可能是导致该患者持续症状和放射学变化的原因之一。
Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes.