NF-kappaB fans the flames of lung carcinogenesis.
NF-kappaB fans the flames of lung carcinogenesis.
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DOI：
10.1158/1940-6207.capr-10-0042
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发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Dranoff G
中科院分区：
文献类型：
--
作者：
Wong KK;Jacks T;Dranoff G
This perspective on Deng et al. (beginning on p. XXX in this issue of the journal) examines the link between nuclear factor kappa B (NF-κB) and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating pro-tumorigenic roles of NF-κB activation in lung cancer pathogenesis. Our growing understanding of the tumor-promoting NF-κB downstream effector pathways could lead to the development of novel approaches for lung-cancer therapy and chemoprevention.
