Cellular toxicity of gentamicin.
Cellular toxicity of gentamicin.
复制标题
庆大霉素的细胞毒性。
DOI：
10.1016/0002-9394(79)90085-0
复制
发表时间：
1979
影响因子：
4.2
通讯作者：
P. Tulkens
中科院分区：
文献类型：
--
作者：
J. Libert;P. Ketelbant;F. Van hoof;G. Aubert;P. Tulkens
结膜下注射庆大霉素可诱导大鼠、家兔和人类结膜成纤维细胞内的溶酶体蓄积过程。在电子显微镜下，积累的物质是由一个粒状材料和多形性层状结构，对应于复杂的脂质的存在。在动物中，其他眼部组织以及通过血流到达的细胞不受影响，但肾脏近曲小管除外，那里有明显的重要病变。虽然在我们的研究中没有检查人类肾脏，但我们相信它们可能存在类似的变化。
Subconjunctival injections of gentamicin induced a lysosomal storage process within the conjunctival fibroblasts in rats, rabbits, and humans. Under electron microscopy, the accumulated substance was composed of a granular material and pleomorphic lamellar structures, corresponding to the presence of complex lipids. In animals, the other ocular tissues as well as the cells reached through the bloodstream remained unaffected, except the proximal convoluted tubules of the kidneys, where important lesions were evident. Although human kidneys were not examined in our study, we believe they might present similar alterations.