Lipid microspheres as novel drug carriers.
Lipid microspheres as novel drug carriers.
复制标题
脂质微球作为新型药物载体。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
Y. Mizushima
中科院分区：
文献类型：
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作者：
Y. Mizushima
总结
皮质类固醇、非甾体抗炎药和前列腺素E1（PGE 1）的脂质微球制剂均显示出比游离药物更强的活性。特别是Lipo-PGE 1在约为游离PGE 1剂量的十分之一时比游离PGE 1显著更有活性。脂质体的大量研究表明，脂质微球是一种很有前途的药物载体。
SUMMARY
Lipid microsphere preparations of corticosteroid, non-steroid anti-inflammatory drugs and prostaglandin E1 (PGE1) all showed more potent activity than the free drugs. Lipo-PGE1 in particular was significantly more active than free PGE1 at about one-tenth the dose of free PGE1. A large mass of data obtained in studies of liposomes suggest many applications for the lipid microsphere, which is considered to be a very promising carrier in drug delivery systems.