Gender Differences in Outpatient Pediatric Drug Utilization: A Cohort Study From Southern Italy
Gender Differences in Outpatient Pediatric Drug Utilization: A Cohort Study From Southern Italy
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DOI：
10.3389/fphar.2019.00011
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发表时间：
2019-02-05
影响因子：
5.6
通讯作者：
Capuano, Annalisa
中科院分区：
文献类型：
--
作者：
Ferrajolo, Carmen;Sultana, Janet;Capuano, Annalisa
目的：本回顾性人群队列研究的目的是深入调查性别特异性药物利用模式在儿科门诊population.Methods：通过使用一个大型的行政数据库的地方卫生单位的卡塞塔（南意大利），儿科队列从出生到18岁，观察了6年（从2010年1月1日至2015年12月31日）。每100名居民的药物使用年流行率以及处方中位数按性别分层。计算2015年最常用活性物质的急性和反复使用的流行率。结果：2010 - 2015年，观察到男女儿童的药物使用流行率呈下降趋势（-3.2%，分发药物的中位数减少）。2015年，任何年龄段儿童中最常用的药物类别是适度的，但男性的处方量始终高于女性：全身抗感染药物（M = 43.5%; F = 42.3%），呼吸道药物（M = 29.0%; F = 26.1%）和激素（M = 13.1%; F = 11.3%）。不分性别，倍氯米松是最常用的活性物质在第一个2年的生活，而此后阿莫西林/克拉维辛combination.Conclusions：在一个大的人口的儿科门诊病人没有重大差异，性别之间，虽然常用的药物类别;特别是抗生素，呼吸道药物和激素与皮质类固醇的全身使用处方量适中，但男性的处方量始终大于女性。
Objective: The aim of this retrospective population-based cohort study is to in-depth investigate gender-specific drug utilization pattern in pediatric outpatient population.Methods: By using a large administrative database of the Local Health Unit of Caserta (Southern Italy), a pediatric cohort from the birth to 18 years was observed over 6 years (from 1st January 2010 to 31st December 2015). Yearly prevalence of drug use per 100 inhabitants as well as the median number of prescriptions was stratifying by gender. Prevalence of acute and recurrent use of the most frequently used active substances was calculated for the year 2015.Results: A decreasing trend in prevalence of drug use (-3.2%, with a reduction of median number of drugs dispensed) was observed in children for both sexes, from 2010 to 2015. In 2015, the drug classes most commonly used among children of any age were modestly but consistently prescribed more to males than to females: systemic anti-infective drugs (M = 43.5%; F = 42.3%), respiratory tract drugs (M = 29.0%; F = 26.1%), and hormones (M = 13.1%; F = 11.3%). Irrespective of gender, beclomethasone was the most utilized active substance in the first 2 years of life, while thereafter amoxicillin/clavulanate in combination.Conclusions: In a large population of pediatric outpatients no major difference was seen between genders, although commonly used drug classes; in particular, antibiotics, respiratory tract drugs and Hormones with corticosteroids for systemic use prescribed modestly but consistently to larger extent in males than females.