Relation of Plasma Fibrinogen Level With the Presence, Severity, and Complexity of Coronary Artery Disease
Relation of Plasma Fibrinogen Level With the Presence, Severity, and Complexity of Coronary Artery Disease
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DOI：
10.1177/1076029616629210
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发表时间：
2017-09-01
影响因子：
2.9
通讯作者：
Kargin, Ramazan
中科院分区：
文献类型：
--
作者：
Tabakci, Mehmet Mustafa;Gerin, Fethullah;Kargin, Ramazan
背景资料：稳定型心绞痛（SAP）患者血浆纤维蛋白原水平与冠状动脉疾病（CAD）的范围、严重程度和复杂程度的关系尚未得到充分研究。本研究的目的是评估血浆纤维蛋白原水平是否与冠状动脉的复杂性，严重程度和程度评估SYNTAX（经皮冠状动脉介入治疗与TAXUS和心脏手术之间的协同作用）score（SS）。测量基线血清纤维蛋白原水平，并计算研究人群的SS。结果：血浆纤维蛋白原水平从对照组到高SS组呈阶梯性升高，其中对照组为0，中度组< 22，高SS组22。纤维蛋白原与SS之间存在强相关性（r = 0.535，P <0.001）。纤维蛋白原受试者工作特征曲线下面积为0.72（95%置信区间[CI] 0.61-0.82; < .001），可预测高SS。纤维蛋白原值高于411 mg/dL预测高SS的敏感性为75%，特异性为64%。在多变量分析中，血浆纤维蛋白原是稳定型CAD患者高SS的独立预测因子（比值比[OR] 1.01; 95%CI，1.01-1.02; P <0.001）。结论：血浆纤维蛋白原是一种易于测量的全身炎症标志物，与CAD患者冠状动脉严重程度和复杂性独立相关。
Background: Relation of plasma fibrinogen levels with extent, severity, and complexity of coronary artery disease (CAD) in patients with stable angina pectoris (SAP) has not been adequately investigated. The aim of this study was to evaluate whether plasma fibrinogen level is associated with coronary complexity, severity, and extent assessed by SYNTAX (Synergy between percutaneous coronary intervention with TAXUS and Cardiac Surgery) score (SS).Methods: We enrolled 134 consecutive patients with SAP who underwent coronary angiography. Baseline serum fibrinogen levels were measured, and SS was calculated from the study population. The patients were classified into 3 groups by tertiles of SS (SS, control group = 0; intermediate group < 22; and high group 22).Results: Plasma fibrinogen levels demonstrated a stepwise increase from control group to high SS group. There was a strong correlation between fibrinogen and the SS (r = .535, P < .001). Area under the receivers operating characteristic curve of fibrinogen was 0.72 (95% confidence interval [CI] 0.61-0.82; < .001) for predicting a high SS. Fibrinogen value higher than 411 mg/dL has a sensitivity of 75% and a specificity of 64% in prediction of high SS. In multivariate analyses, plasma fibrinogen was observed to be an independent predictor for high SS in patients with stable CAD (odds ratio [OR] 1.01; 95% CI, 1.01-1.02; P < .001).Conclusion: Plasma fibrinogen is a readily measurable systemic inflammatory marker and is independently associated coronary severity and complexity in patients with CAD.