One is Nothing without the Other: Theoretical and Empirical Analysis of Cell Growth and Cell Cycle Progression.
One is Nothing without the Other: Theoretical and Empirical Analysis of Cell Growth and Cell Cycle Progression.
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DOI：
10.1016/j.jmb.2019.04.004
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发表时间：
2019-05
影响因子：
5.6
通讯作者：
P. Levin;Sattar Taheri-Araghi
中科院分区：
文献类型：
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作者：
P. Levin;Sattar Taheri-Araghi
生长迅速的小细菌是遗传和定量分析的理想对象。长期以来，一直是理论家的宠儿，研究细菌系统中细胞生长和细胞周期进程之间的关系的努力得到了模型师和经验主义者的同等程度的推动。从历史的角度来看，我们在这里分析了这一领域的早期工作，它对如何理解和询问细菌细胞周期的影响，以及高通量技术的出现带来的变化，用于分析培养中的单个细菌细胞。
Small, fast-growing bacteria make ideal subjects for genetic and quantitative analysis alike. Long the darling of theoreticians, efforts to understand the relationship between cell growth and cell cycle progression in bacterial systems have been propelled by modelers and empiricist in equal measure. Taking a historical approach, here we break down early work in this area, the impact it had on how the bacterial cell cycle is understood and interrogated, and changes brought by the advent of high-throughput techniques for the analysis of individual bacterial cells in culture.