Autophagy in organelle homeostasis: Peroxisome turnover
Autophagy in organelle homeostasis: Peroxisome turnover
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DOI：
10.1016/j.mam.2006.08.004
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发表时间：
2006-10-01
影响因子：
10.6
通讯作者：
Klionsky, Daniel J.
中科院分区：
文献类型：
--
作者：
Monastyrska, Iryna;Klionsky, Daniel J.
当细胞外液中的营养供应不足时，它们可能会开始吃掉一些内部蛋白质以及整个细胞器，以重新用于合成新的成分。这个过程被称为自噬，它涉及细胞内形成双膜结构，将待降解的物质包裹在称为自噬体的囊泡中。自噬体随后与溶酶体/液泡融合，溶酶体/液泡的水解酶降解被隔离的细胞器。过氧化物酶体的降解是一种特定类型的自噬，其以选择性的方式发生，并且主要在酵母中进行研究。最近，据报道，在具有增殖的过氧化物酶体的哺乳动物细胞中发生类似的选择性自噬过程。在这里，我们讨论了哺乳动物细胞中过氧化物酶体自噬的特点，并提出了一个全面的模型，其可能的机制的基础上，从其他系统的已知和共同的元素降解。(c)2006爱思唯尔有限公司保留所有权利。
When cells are confronted with an insufficient supply of nutrients in their extracellular fluid, they may begin to cannibalize some of their internal proteins as well as whole organelles for reuse in the synthesis of new components. This process is termed autophagy and it involves the formation of a double-membrane structure within the cell, which encloses the material to be degraded into a vesicle called an autophagosome. The autophagosome subsequently fuses with a lysosome/vacuole whose hydrolytic enzymes degrade the sequestered organelle. Degradation of peroxisomes is a specific type of autophagy, which occurs in a selective manner and has been mostly studied in yeast. Recently, it was reported that a similar selective process of autophagy occurs in mammalian cells with proliferated peroxisomes. Here we discuss characteristics of the autophagy of peroxisomes in mammalian cells and present a comprehensive model of their likely mechanism of degradation on the basis of known and common elements from other systems. (c) 2006 Elsevier Ltd. All rights reserved.