The effect of connective tissue material uncertainties on knee joint mechanics under isolated loading conditions.
The effect of connective tissue material uncertainties on knee joint mechanics under isolated loading conditions.
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DOI：
10.1016/j.jbiomech.2010.08.005
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发表时间：
2010-12-01
影响因子：
2.4
通讯作者：
Barry, Megan
中科院分区：
文献类型：
--
作者：
Dhaher, Yasin Y.;Kwon, Tae-Hyun;Barry, Megan
尽管结缔组织参数的变异性已被广泛报道和认可，但缺乏对这种参数不确定性对从完整解剖关节模型得出的预测的影响的系统检查。因此，进行了敏感性分析，以考虑具有在给定区间内变化的结缔组织材料参数的三维非线性有限元膝关节模型的行为。该模型包括胫骨-股骨和髌股自由度的耦合力学。包括七个被建模为非线性连续体的初级结缔组织、被线性弹性模型描述的关节软骨以及被建模为横向各向同性弹性材料的半月板。在这项研究中，提出了一种多因素全局敏感性分析，它可以检测有影响的材料参数的贡献，同时保持参数相互作用的潜在影响。为了说明材料不确定性对模型预测的影响，使用了许多孤立的实验范式中报告的示例加载条件。我们的研究结果表明，在耦合的胫骨-股骨和髌骨-股骨模型中包含材料不确定性揭示了生物力学相互作用，否则这些相互作用将仍然未知。例如，我们的分析表明，与髌股关节固有组织材料参数相关的变化相比，在一定屈曲角度范围内，前十字韧带参数变化对髌股运动学和动力学响应敏感性的影响明显更大。我们认为，本文提出的系统敏感性框架将有助于识别值得进一步研究的关键材料不确定性，并提供对那些可能与给定响应不相关的不确定性的见解。
Although variability in connective tissue parameters is widely reported and recognized, systematic examination of the effect of such parametric uncertainties on predictions derived from a full anatomical joint model is lacking. As such, a sensitivity analysis was performed to consider the behavior of a three-dimensional, non-linear, finite element knee model with connective tissue material parameters that varied within a given interval. The model included the coupled mechanics of the tibio-femoral and patellofemoral degrees of freedom. Seven primary connective tissues modeled as nonlinear continua, articular cartilages described by a linear elastic model, and menisci modeled as transverse isotropic elastic materials were included. In this study, a multi-factorial global sensitivity analysis is proposed, which can detect the contribution of influential material parameters while maintaining the potential effect of parametric interactions. To illustrate the effect of material uncertainties on model predictions, exemplar loading conditions reported in a number of isolated experimental paradigms were used. Our findings illustrated that the inclusion of material uncertainties in a coupled tibio-femoral and patello-femoral model reveals biomechanical interactions that otherwise would remain unknown. For example, our analysis revealed that the effect of anterior cruciate ligament parameter variations on the patello-femoral kinematic and kinetic response sensitivities were significantly larger, over a range of flexion angles, when compared to variations associated with material parameters of tissues intrinsic to the patello-femoral joint. We argue that the systematic sensitivity framework presented herein will help identify key material uncertainties that merit further research, as well as provide insight on those uncertainties that may not be as relative to a given response.
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