Mycemycins A-E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes.
Mycemycins A-E, New Dibenzoxazepinones Isolated from Two Different Streptomycetes.
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霉素 A–E，从两种不同的链霉菌中分离出的新型二苯并氧氮杂酮类药物
DOI：
10.3390/md13106247
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发表时间：
2015-09-30
期刊：
影响因子：
5.4
通讯作者：
Huang Y
中科院分区：
文献类型：
--
作者：
Liu N;Song F;Shang F;Huang Y
从两种不同链霉菌的菌丝体乙醇提取物中分离得到5个新的二苯并恶氮酮类化合物，即霉菌素A-E(1-5)。1和2是从酸性红壤来源的链霉菌中分离到的。FXJ1.235和3-5来自一个名为橄榄链霉菌FXJ8.012Δ1741的GntR基因破坏的深海菌株。通过一维和二维核磁共振等波谱分析，确定了霉菌素的结构。
Five new dibenzoxazepinone derivatives, mycemycins A–E (1–5), were isolated from the ethanol extracts of mycelia of two different streptomycetes. 1 and 2 were isolated from an acidic red soil-derived strain, Streptomyces sp. FXJ1.235, and 3–5 from a gntR gene-disrupted deep-sea strain named Streptomyces olivaceus FXJ8.012Δ1741. The structures of mycemycins were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR techniques.