AN OUTBREAK OF HEPATITIS-B ASSOCIATED WITH JET INJECTIONS IN A WEIGHT-REDUCTION CLINIC
AN OUTBREAK OF HEPATITIS-B ASSOCIATED WITH JET INJECTIONS IN A WEIGHT-REDUCTION CLINIC
复制标题
DOI：
10.1001/archinte.150.9.1923
复制
发表时间：
1990-09-01
影响因子：
--
通讯作者：
HORAN, JM
中科院分区：
文献类型：
--
作者：
CANTER, J;MACKEY, K;HORAN, JM
从1984年1月到1985年11月，减肥门诊（门诊1）的就诊者中出现了31例乙型肝炎临床病例。发病前，每个病例均在诊所 1 接受了一系列由喷射注射器注射的人绒毛膜促性腺激素注射。在 1985 年前 6 个月到诊所 1 就诊的 341 名患者中，有 287 人 (84%) 获得了临床病史、危险因素评估、血清学评估和诊所注射记录审查。在该队列中，21% (60/287) 曾接受过注射。 乙型肝炎病毒急性感染的证据（记录的临床病例或乙型肝炎核心抗原抗体，IgM 阳性）。在研究期间在诊所接受过人绒毛膜促性腺激素的患者中，仅通过喷射注射器接受人绒毛膜促性腺激素的患者中有 24% (57/239) 经历过急性乙型肝炎病毒感染。 22名仅接受注射器注射的人中，没有人感染乙型肝炎病毒。 1985 年 7 月 2 日，1 号诊所停止使用喷射注射器，与此次疫情的结束有关。这项调查表明，喷射注射器可能会被乙型肝炎病毒污染，然后可能成为其传播的载体。
From January 1984 through November 1985, 31 clinical cases of hepatitis B occurred among attendees of a weight reduction clinic (clinic 1). Before the onset of illness, each case-patient had received a series of injections of human chorionic gonadotropin administered by jet injectors at clinic 1. Clinical history, risk factor assessment, serologic evaluation, and review of clinic injection records were obtained on 287 (84%) of 341 persons who had attended clinic 1 in the first 6 months of 1985. Of this cohort, 21% (60/287) had evidence of acute infection with hepatitis B virus (either documented clinical cases or antibody to hepatitis B core antigen, IgM positive). Of persons who had been given human chorionic gonadotropin at the clinic during the period studied, 24% (57/239) of those receiving human chorionic gonadotropin only by jet injector experienced acute hepatitis B virus infection. None of the 22 persons who had received injections only by syringe experienced hepatitis B virus infection. Stopping the use of the jet injectors on July 2, 1985, at clinic 1, was associated with the termination of this outbreak. This investigation demonstrated that jet injectors can become contaminated with hepatitis B virus and then may be vehicles for its transmission.