Neurochemicals and respiratory control during development.
Neurochemicals and respiratory control during development.
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发育过程中的神经化学物质和呼吸控制。
DOI：
10.1152/jappl.1989.67.1.1
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Inman,JG
中科院分区：
文献类型：
--
作者：
Moss,IR;Inman,JG
在个体发育过程中，中枢神经系统经历神经元生长、退化和重塑。神经递质和调节器系统的开发是一个可塑过程，每个系统都有各自的时间特征。这些特征包括神经化学物质的合成、降解或摄取，以及很大程度上独立的受体的出现。个体发育过程中的信息传递因这些系统的可变发展以及这些化学物质之间的共存和协同功能而变得复杂。讨论了九种神经化学系统：腺苷、γ-氨基丁酸、阿片类药物、前列腺素、血清素、黄体酮、P 物质、促甲状腺激素释放激素和儿茶酚胺。根据预先确定的标准评估这些因素在自然围产期呼吸控制中的可能作用。这些包括呼吸相关区域中物质系统的存在，这些区域中其浓度的生理上适当的变化，激动剂和拮抗剂引起的呼吸效应，以及在假定的生理过程激活期间用拮抗剂消除物质的作用。有人认为抑制性神经调节剂水平过高或神经化学物质之间的不平衡可以部分解释围产期呼吸控制的特殊特征。
During ontogeny, the central nervous system undergoes neuronal growth, regression, and remodeling. The development of neurotransmitter and modulator systems is a plastic process with individual temporal characteristics for each system. These characteristics include the synthesis, degradation, or uptake of neurochemicals and, largely independently, the appearance of their receptors. Message transmission during ontogeny is compounded by the variable development of these systems and by the coexistence and cofunction among these chemicals. Nine neurochemical systems are discussed: adenosine, gamma-aminobutyric acid, opioids, prostaglandins, serotonin, progesterone, substance P, thyrotropin-releasing hormone, and the catecholamines. The possible role of each of these in natural perinatal respiratory control is evaluated according to predetermined criteria. These include the presence of a substance system in respiratory-related regions, physiologically appropriate changes in its concentration in these regions, elicitation of respiratory effects by agonists and antagonists, and abolition with an antagonist of the effect of a substance during its presumed activation by a physiological process. It is suggested that excessive levels of suppressant neuromodulators or an imbalance among neurochemicals can partly explain the special features of respiratory control in the perinatal period.