Pain-related opioidergic and dopaminergic neurotransmission: Dual meta-Analyses of PET radioligand studies.
Pain-related opioidergic and dopaminergic neurotransmission: Dual meta-Analyses of PET radioligand studies.
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疼痛相关的阿片能和多巴胺能神经传递：PET 放射性配体研究的双重荟萃分析。
DOI：
10.1016/j.brainres.2023.148268
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发表时间：
2023
期刊：
影响因子：
2.9
通讯作者：
Strigo,IrinaA
中科院分区：
文献类型：
--
作者：
GarciaGuerra,Sergio;Spadoni,Andrea;Mitchell,Jennifer;Strigo,IrinaA
在人脑中与疼痛相关的经历中阿片能和多巴胺能处理之间相互作用的分子机制仍不完全清楚。这部分是由于可视化和测量代谢活动的可用技术的侵入性。使用放射性物质的正电子发射断层扫描 (PET) 放射性配体研究仍然是迄今为止唯一可用于研究人脑分子机制的方法。最常研究的 PET 放射性示踪剂是与阿片受体结合的 [11C]-卡芬太尼 (CFN) 和 [11C]- 或 [18F]-二丙诺啡 (DPN)，以及与多巴胺受体结合的 [11C]-雷氯必利 (RAC) 和 [18F]-fallypride (FAL) 示踪剂。当前的荟萃分析检查了使用上述阿片类药物和多巴胺放射性配体的疼痛相关研究，以期将可用数据整合到最有可能激活的区域。我们的主要目标是使用受试者内方法确定疼痛相关经历期间共享阿片类药物/多巴胺神经传递的区域。对先前发表的体素坐标数据进行基于种子的 d Mapping (SDM) 分析表明，阿片样物质激活在双侧尾状核、丘脑、右壳核、扣带回、中脑、额下回和左颞上回最强。多巴胺能研究表明，双侧尾状核、丘脑、右壳核、扣带回和左壳核的激活程度最高。在与疼痛相关的经历中，我们能够看到大多数区域的阿片类药物和多巴胺激活之间存在明显的重叠，尽管存在一些独特的多巴胺能激活区域，例如左壳核。阿片能激活的独特区域包括中脑、额下回和左颞上回。在这里，我们提供了人类厌恶状态下阿片能和多巴胺能处理之间功能重叠的初步证据。
Molecular mechanisms of the interaction between opioidergic and dopaminergic processing during pain-related experiences in the human brain are still incompletely understood. This is partially due to the invasive nature of the available techniques to visualize and measure metabolic activity. Positron Emission Tomography (PET) radioligand studies using radioactive substances are still the only available modality to date that allows for the investigation of the molecular mechanisms in the human brain. The most commonly studied PET radiotracers are [11C]-carfentanil (CFN) and [11C]- or [18F]-diprenorphine (DPN), which bind to opioid receptors, and [11C]-raclopride (RAC) and [18F]-fallypride (FAL) tracers, which bind to dopamine receptors. The currentmeta-analysis examines pain-related studies that used aforementioned opioid and dopamine radioligands in an effort to consolidate the available data into the most likely activated regions. Our primary goal was to identify regions of shared opioid/dopamine neurotransmission during pain-related experiences using within-subject approach. Seed-based d Mapping (SDM) analysis of previously published voxel coordinate data showed that opioidergic activations were strongest in the bilateral caudate, thalamus, right putamen, cingulate gyrus, midbrain, inferior frontal gyrus, and left superior temporal gyrus. The dopaminergic studies showed that the bilateral caudate, thalamus, right putamen, cingulate gyrus, and left putamen had the highest activations. We were able to see a clear overlap between opioid and dopamine activations in a majority of the regions during pain-related experiences, though there were some unique areas of dopaminergic activation such as the left putamen. Regions unique to opioidergic activation included the midbrain, inferior frontal gyrus, and left superior temporal gyrus. Here we provide initial evidence for the functional overlap between opioidergic and dopaminergic processing during aversive states in humans.