Metal-organic framework MIL-101(Cr) for high-performance liquid chromatographic separation of substituted aromatics.
Metal-organic framework MIL-101(Cr) for high-performance liquid chromatographic separation of substituted aromatics.
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DOI：
10.1021/ac201517c
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发表时间：
2011-08
影响因子：
7.4
通讯作者：
Cheng‐Xiong Yang;Xiu‐Ping Yan
中科院分区：
文献类型：
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作者：
Cheng‐Xiong Yang;Xiu‐Ping Yan
不同的结构和孔拓扑结构，可访问的笼和隧道，以及高表面积使金属有机框架作为分离科学中的新型介质具有吸引力。本文报道了MIL-101（Cr）浆态填充柱用于取代芳烃的高效液相色谱分离。采用MIL-101（Cr）填充柱（5cm长× 4.6mm i.d.）提供了高分辨率的分离乙苯（EB）和二甲苯，二氯苯和氯甲苯异构体，和EB和苯乙烯。在MIL-101（Cr）填料柱上，乙苯和苯乙烯混合物中的典型杂质甲苯和邻二甲苯也得到了有效分离。EB、间二氯苯和间氯甲苯的柱效分别为20000、13000和10000塔板m（-1）。取代芳烃的保留时间、峰面积、峰高和半峰宽的五次重复分离的相对标准偏差分别为0.2- 0.7%、0.9- 2.9%、0.5- 2.1%和0.6-2.7%。MIL-101（Cr）对邻位异构体具有高亲和力，使用二氯甲烷作为移动的相，可在3 min内快速选择性地将邻位异构体与其他异构体分离。研究了移动的相组成、注入样品质量和温度的影响。MIL-101（Cr）上二甲苯、二氯苯和氯甲苯的分离受熵变控制，而EB和苯乙烯在MIL-101（Cr）上的分离受焓变控制。
The diverse structures and pore topologies, accessible cages and tunnels, and high surface areas make metal-organic frameworks attractive as novel media in separation sciences. Here we report the slurry-packed MIL-101(Cr) column for high-performance liquid chromatographic separation of substituted aromatics. The MIL-101(Cr) packed column (5 cm long × 4.6 mm i.d.) offered high-resolution separation of ethylbenzene (EB) and xylene, dichlorobenzene and chlorotoluene isomers, and EB and styrene. The typical impurities of toluene and o-xylene in EB and styrene mixtures were also efficiently separated on the MIL-101(Cr) packed column. The column efficiencies for EB, m-dichlorobenzene, and m-chlorotoluene are 20000, 13000, and 10000 plates m(-1), respectively. The relative standard deviation for five replicate separations of the substituted aromatics was 0.2-0.7%, 0.9-2.9%, 0.5-2.1%, and 0.6-2.7% for the retention time, peak area, peak height, and half peak width, respectively. The MIL-101(Cr) offered high affinity for the ortho-isomer, allowing fast and selective separation of the ortho-isomer from the other isomers within 3 min using dichloromethane as the mobile phase. The effects of the mobile phase composition, injected sample mass, and temperature were investigated. The separation of xylene, dichlorobenzene, and chlorotoluene on MIL-101(Cr) was controlled by entropy change, while the separation of EB and styrene on MIL-101(Cr) was governed by enthalpy change.