INCREASING INCIDENCE OF ADENOVIRUS DISEASE IN BONE-MARROW TRANSPLANT RECIPIENTS
INCREASING INCIDENCE OF ADENOVIRUS DISEASE IN BONE-MARROW TRANSPLANT RECIPIENTS
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DOI：
10.1093/infdis/169.4.775
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发表时间：
1994-04-01
影响因子：
6.4
通讯作者：
CASPER, JT
中科院分区：
文献类型：
--
作者：
FLOMENBERG, P;BABBITT, J;CASPER, JT
Adenovirus infections in 201 bone marrow transplant (BMT) recipients over 4 years were retrospectively reviewed. Forty-two patients (20.9%) had positive adenovirus cultures after BMT. There was a higher incidence of adenovirus infections in pediatric patients than in adults (31.3% vs. 13.6%, P = .003). In addition, the time of onset of adenovirus infection after transplant was earlier in pediatric patients (mean, 90 days). Adenovirus type 35 was the most common serotype identified. One-third of adenovirus-positive patients had definite or probable adenovirus disease. Moderate to severe acute graft-versus-host disease and isolation of adenovirus from two or more sites were significant risk factors for adenovirus disease. This report documents a higher incidence of both adenovirus infection and disease than do previous studies. Adenovirus may emerge as a more frequent pathogen as more high-risk BMT transplants are done.
