Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?
Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?
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DOI：
10.1111/mec.13762
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发表时间：
2016-09-01
影响因子：
4.9
通讯作者：
Walton, Catherine
中科院分区：
文献类型：
--
作者：
Bennett, Kelly Louise;Shija, Fortunate;Walton, Catherine
日益全球化促进了包括疾病媒介在内的外来物种的传播。了解此类殖民化所涉及的进化过程不仅具有内在的生物学意义，而且对于预测和减轻未来的疾病风险也很重要。埃及伊蚊是登革热、基孔肯雅热和寨卡病毒的主要传播媒介，伊蚊促进了其在全球范围内的传播。埃及伊蚊对人类改造环境的适应。了解这种入侵所涉及的进化过程需要对源种群的遗传组成进行表征。应用近似贝叶斯计算 (ABC) 对四个核标记和一个线粒体标记的测序数据显示，非洲伊蚊群体。埃及伊蚊最适合谱系多样化、历史混合和近期人口结构的人口模型。作为祖先Ae。埃及伊蚊依赖于森林，这一种群历史与更新世气候变化驱动的森林破碎和扩张的影响是一致的。或者或另外，历史上人类在非洲大陆的移动可能促进了它们最近的传播和混合。 ABC 分析和单倍型网络支持早期关于单个非洲以外殖民事件的推论，而遗传多样性下降的谱系表明，Ae。埃及伊蚊首先从非洲迁移到美洲，然后又迁移到亚洲。 ABC 分析无法验证该定植途径，可能是因为混合物的遗传信号掩盖了真正的定植途径。通过增加遗传多样性和形成新的等位基因组合，非洲内部的分化和历史混合可能为伊蚊在全球范围内的成功传播提供了所需的适应性潜力。埃及伊蚊。
Increasing globalization has promoted the spread of exotic species, including disease vectors. Understanding the evolutionary processes involved in such colonizations is both of intrinsic biological interest and important to predict and mitigate future disease risks. The Aedes aegypti mosquito is a major vector of dengue, chikungunya and Zika, the worldwide spread of which has been facilitated by Ae. aegypti's adaption to human-modified environments. Understanding the evolutionary processes involved in this invasion requires characterization of the genetic make-up of the source population (s). The application of approximate Bayesian computation (ABC) to sequence data from four nuclear and one mitochondrial marker revealed that African populations of Ae. aegypti best fit a demographic model of lineage diversification, historical admixture and recent population structuring. As ancestral Ae. aegypti were dependent on forests, this population history is consistent with the effects of forest fragmentation and expansion driven by Pleistocene climatic change. Alternatively, or additionally, historical human movement across the continent may have facilitated their recent spread and mixing. ABC analysis and haplotype networks support earlier inferences of a single out-of-Africa colonization event, while a cline of decreasing genetic diversity indicates that Ae. aegypti moved first from Africa to the Americas and then to Asia. ABC analysis was unable to verify this colonization route, possibly because the genetic signal of admixture obscures the true colonization pathway. By increasing genetic diversity and forming novel allelic combinations, divergence and historical admixture within Africa could have provided the adaptive potential needed for the successful worldwide spread of Ae. aegypti.