OTOTOXIC EFFECTS OF THE INTERACTION BETWEEN KANAMYCIN AND ETHACRYNIC-ACID - COCHLEAR ULTRASTRUCTURE CORRELATED WITH COCHLEAR POTENTIALS AND KANAMYCIN LEVELS
OTOTOXIC EFFECTS OF THE INTERACTION BETWEEN KANAMYCIN AND ETHACRYNIC-ACID - COCHLEAR ULTRASTRUCTURE CORRELATED WITH COCHLEAR POTENTIALS AND KANAMYCIN LEVELS
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DOI：
10.3109/00016487909137181
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发表时间：
1979-01-01
影响因子：
1.4
通讯作者：
BRUMMETT, RE
中科院分区：
文献类型：
--
作者：
RUSSELL, NJ;FOX, KE;BRUMMETT, RE
用卡那霉素(Kan)400 mg/kg预先处理2 h的豚鼠，研究了EA(40 mg/kg)给药后3、4、6、24 h卡那霉素(Kan)与乙基丙烯酸(EA)相互作用对豚鼠耳蜗超微结构的影响。生理盐水(SAL)对照组给予4种处理：Kan/Ea、Kan/Sal、Sal/Ea和Sal/Sal。Corti器外毛细胞在3h出现核和质膜改变，至24h完全破坏，内毛细胞未受影响。Kan/EA组和SAL/EA组动物在3h出现严重的血管纹肿胀，至24h消失，Kan/EA组比SAL/EA组作用更大。这些结果与药物对交直流电蜗内电位影响的时程一致。外淋巴液中Kan浓度不受电针处理的影响。
The effects of the interaction between kanamycin (KAN) and ethacrynic acid (EA) on the ultrastructure of the guinea pig cochlea were studied 3, 4, 6 and 24 h following administration of EA (40 mg/kg) to animals pretreated 2 h earlier with KAN (400 mg/kg). Appropriate saline (SAL) controls were included giving 4 treatments: KAN/EA, KAN/SAL, SAL/EA and SAL/SAL. The outer hair cells of the organ of Corti showed nuclear and plasma membrane changes at 3 h and were completely destroyed by 24 h. The inner hair cells were unaffected. Severe swelling was seen in the stria vascularis of both KAN/EA and SAL/EA animals at 3 h and was gone by 24 h. KAN/EA had a greater effect on the stria than had SAL/EA. These results were consistent with the time course of the effect of the drugs on the AC and DC endocochlear potentials. KAN concentrations in perilymph were unaffected by treatment with EA.