Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.
Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons.
复制标题
DOI：
10.1007/s00213-012-2851-5
复制
发表时间：
2013-02
影响因子：
3.4
通讯作者：
Weerts, Elise M.
中科院分区：
文献类型：
--
作者：
Goodwin, Amy K.;Kaminski, Barbara J.;Weerts, Elise M.
关键词：
Gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) are gamma-hydroxybutyrate (GHB) pro-drugs and drugs of abuse. Given the reports of abuse, and the ease at which GBL and 1,4-BD may be obtained, we investigated the reinforcing of GBL (n=5) and 1,4-BD (n=4) in baboons using IV self-administration procedures. Sessions ran 24 h/day. Each injection was contingent upon completion of a fixed number (120 or 160) of lever responses. A 3-h timeout period followed each injection, limiting the total number of injections to 8/day. Self-administration was first established with cocaine (0.32 mg/kg/injection). GBL (10–130.0 mg/kg/injection), 1,4-BD (10–100 mg/kg/injection) or vehicle were substituted for cocaine at least 15 days. Food pellets were available ad libitum 24 h/day and were contingent upon completion of 10 lever responses. GBL (32–100 mg/kg/injection) maintained significantly greater numbers of injections when compared to vehicle in 4 of 5 baboons and mean rates of injection were high (>6 per day) in 3 baboons and moderate in the fourth baboon (4–6 per day). 1,4-BD (78–130 mg/kg/injection) maintained significantly greater numbers of injections when compared to vehicle in only 2 out of 4 baboons and rates were moderate to high in both baboons. Self-injection of these doses of GBL and 1,4-BD generally inhibited food-maintained responding. GBL and 1,4-BD have abuse liability. Given that GBL and 1,4-BD are self-administered, are easier to obtain than GHB, and are detected in seized samples, additional legal control measures of these GHB pro-drugs may be needed.
登录
查看更多内容
影响因子：
3.4
作者：
Ator, NA
通讯作者：
Ator, NA
影响因子：
6
作者：
Bell, James;Collins, Rodney
通讯作者：
Collins, Rodney
影响因子：
2
作者：
Hillebrand, Jennifer;Olszewski, Deborah;Sedefov, Roumen
通讯作者：
Sedefov, Roumen
影响因子：
3.4
作者：
Beardsley, PM;Balster, RL;Harris, LS
通讯作者：
Harris, LS
影响因子：
4.2
作者：
Goodwin, Amy K.;Kaminski, Barbara J.;Griffiths, Roland R.;Ator, Nancy A.;Weerts, Elise M.
通讯作者：
Weerts, Elise M.