[Isolated granulocytic sarcoma in the breast].
[Isolated granulocytic sarcoma in the breast].
复制标题
[乳房孤立性粒细胞肉瘤]。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Masatomo Takahashi
中科院分区：
文献类型：
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作者：
K. Oyama;Takao Suzuki;S. Yoshimura;Michiko Irei;K. Oyama;M. Koike;Masatomo Takahashi
一位16岁的女性，在右乳房肿瘤活检后被诊断为非霍奇金淋巴瘤，住进了我院。由于病理结果怀疑肉瘤，转诊医院的诊断未得到再次确认。由于住院后10天对侧乳房出现另一个肿瘤，因此进行了第二次肿瘤活检。肿瘤触诊标本髓过氧化物酶和萘酚AS-D氯乙酸酯酶染色阳性。诊断为粒细胞肉瘤（GS）。此时外周血和骨髓中未发现异常。骨髓染色体检查正常。WT-1 mRNA的拷贝数在骨髓细胞和肿瘤细胞中均较高。外周血中未检测到WT-1 mRNA的表达。她接受了与急性髓性白血病相同的治疗方案，乳腺肿瘤消失。骨髓中WT-1 mRNA滴度略有下降，但仍保持较高水平。综上所述，这些发现表明GS似乎是骨髓来源，WT-1 mRNA的监测可能有助于任何复发的早期诊断。
A 16-year-old female, who was diagnosed as having non-Hodgkin lymphoma following a biopsy of a tumor of her right breast, was admitted to our hospital. The diagnosis made by the referring hospital was not reconfirmed because of the pathological findings with suspicion of sarcoma. As another tumor appeared in the contralateral breast 10 days after hospitalization, a second biopsy of the tumor was performed. Touch preparations of the tumor were positive for myeloperoxidase and naphthol AS-D chloroacetate esterase staining. The diagnosis of granulocytic sarcoma (GS) was made. No abnormalities were found in the peripheral blood and bone marrow at this time. Chromosomal examination of the bone marrow was normal. The number of copies for WT-1 mRNA was high both in the bone marrow cells and the tumor cells. The expression of WT-1 mRNA in peripheral blood was not detected. She was treated with the same protocol as for acute myelogenous leukemia and the breast tumor disappeared. The titer of WT-1 mRNA in bone marrow slightly decreased but remained high. Taken together, these findings suggest that the GS seems to be bone marrow origin and the monitoring of WT-1 mRNA may be useful for early diagnosis of any relapse.