Effects of laser in situ keratomileusis (LASIK) on the corneal endothelium
Effects of laser in situ keratomileusis (LASIK) on the corneal endothelium
复制标题
DOI：
10.1016/s0002-9394(99)80186-x
复制
发表时间：
1998-04-01
影响因子：
4.2
通讯作者：
Edelhauser, HF
中科院分区：
文献类型：
--
作者：
Jones, SS;Azar, RG;Edelhauser, HF
目得：为评价准分子激光原位角膜磨镶术（LASIK）对角膜内皮的影响，方法：在一项前瞻性研究中，对65例（平均年龄41岁，范围22 ~ 66岁）连续患者的98只眼在LASIK矫正2.75 ~ 14.5D近视之前、之后2周和之后12周拍摄角膜内皮。理论消融深度为角膜表面以下200至330 μ m。细胞密度、变异系数和六边形细胞的百分比使用来自每个图像的150至200个细胞来确定。59例患者中88只眼（91%）有接触透镜配戴史。结果：术前内皮细胞密度平均值± SD为2,549 ± 365个细胞/mm 2，平均变异系数为0.35 ± 0.06，在2周时，平均内皮细胞密度或细胞大小的平均变异系数没有统计学显著变化（2，561 +/- 360细胞/mm（2）和0.35 +/- 0.06）或12周（2，541 +/- 364细胞/mm（2）和0.35 +/- 0.05）术后检查。术后2周，六角形细胞的百分比没有显著变化;然而，术后12周（P = 0.0413，双尾t检验），六角形细胞的百分比下降了1%.Conclusions：LASIK矫正高达14.5D的近视后2周和12周，角膜内皮细胞密度和形态没有变化。在这项LASIK研究中，高达14.5屈光度的近视矫正似乎对角膜内皮细胞密度或形态没有临床显著影响。(C)1998年，Elsevier Science Inc. All rights reserved.
PURPOSE: To assess the effects of laser in situ keratomileusis (LASIK) on the corneal endothelium,METHODS: In a prospective study, the corneal endothelium of 98 eyes of 65 consecutive patients (mean age, 41 years; range, 22 to 66 years) was photographed before, 2 weeks after, and 12 weeks after LASIK for the correction of 2.75 to 14.5 diopters of myopia. Theoretical ablation depths were 200 to 330 mu m below the corneal surface. Cell density, coefficient of variation, and percent of hexagonal cells were determined using 150 to 200 cells from each image. Eighty-eight eyes (91%) of 59 patients had a history of contact lens wear,RESULTS: The mean +/- SD preoperative endothelial cell density was 2,549 +/- 365 cells per mm(2), and the mean coefficient of variation was 0.35 +/- 0.06, There was no statistically significant change in the mean endothelial cell density or mean coefficient of variation of cell size at the 2 week (2,561 +/- 360 cells per mm(2) and 0.35 +/- 0.06) or 12-week (2,541 +/- 364 cells per mm(2) and 0.35 +/- 0.05) postoperative examinations. The percent of hexagonal cells was not significantly changed 2 weeks postoperatively; however, 12 weeks postoperatively (P = .0413, two-tailed t test), the percent of hexagonal cells was decreased by 1%.CONCLUSIONS: Corneal endothelial cell density and morphology were unchanged 2 and 12 weeks after LASIK for the correction of up to 14.5 diopters of myopia. In this LASIK study, the correction of up to 14.5 diopters of myopia appears to cause no clinically significant effect on corneal endothelial cell density or morphology. (C) 1998 by Elsevier Science Inc. All rights reserved.