The herbal medicine Dai-Kenchu-To directly stimulates colonic motility
The herbal medicine Dai-Kenchu-To directly stimulates colonic motility
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DOI：
10.1007/s00595-008-3810-y
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发表时间：
2009-02-01
期刊：
影响因子：
2.5
通讯作者：
Yanaga, Katsuhiko
中科院分区：
文献类型：
--
作者：
Kawahara, Hidejiro;Yanaga, Katsuhiko
大kenchuto （DKT）作为一种改善术后肠梗阻症状的药物引起了人们的关注。然而，其作用的具体机制尚不清楚。本文采用一种新颖的方法评价DKT对结肠运动的影响。八名健康的男性志愿者被招募，他们了解这项研究的目的。用生理盐水溶解大芩素（5 g），通过结肠镜进入盲肠，直至升结肠膨胀。超声观察结肠运动30min。DKT进入升结肠后观察到结肠收缩129.4（范围110-145）s。右结肠内各节段被月牙形褶皱分隔，独立收缩。另一方面，在升结肠单独给予生理盐水溶液后，右结肠未见结肠收缩。总之，DKT在给药后立即刺激结肠运动，就像它对上消化道的作用一样。
Dai-kenchu-to (DKT) has attracted attention as a drug that improves the symptoms of postoperative ileus. However, the detailed mechanism of its action still remains unknown. The effect of DKT on colonic motility was herein evaluated using an original method. Eight healthy male volunteers who understood the purpose of this study were enrolled. Dai-kenchu-to (5 g) was dissolved in saline and administered into the cecum using a colonoscope until the ascending colon became distended. Colonic motility was observed by extrasomatic ultrasonography for 30 min. Colonic contractions were observed 129.4 (range 110-145) s after DKT administration into the ascending colon. Every segment in the right colon divided by the crescentic folds contracted independently. On the other hand, no colonic contractions were observed in the right colon after saline solution alone was administered to the ascending colon. In conclusion, DKT stimulates colonic motility immediately after administration, in the same manner as it does for the upper alimentary tract.