Electroacupuncture restores impaired gastric accommodation in vagotomized dogs
Electroacupuncture restores impaired gastric accommodation in vagotomized dogs
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DOI：
10.1023/b:ddas.0000042240.05247.01
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发表时间：
2004-09-01
影响因子：
3.1
通讯作者：
Chen, JDZ
中科院分区：
文献类型：
--
作者：
Hui, OY;Xing, JH;Chen, JDZ
本研究旨在探讨电针对胃调节功能受损犬模型的影响。在10只犬的胃中长期植入胃插管。其中5只犬行迷走神经干切断术。将连接在导管末端的聚乙烯袋通过套管放置在近端胃中。分别在两天内使用胃恒压器和不使用EA评估胃顺应性、胃张力和餐后胃适应性。结果如下。（1）迷走神经切断犬餐后胃容积增加180.8 ± 54.3ml，明显低于正常犬餐后胃容积增加317.3 ± 37.3ml（P < 0.05）。（2）电针对正常犬胃顺应性、基础胃张力和餐后胃调节无明显影响。（3）电针对迷走神经切断犬的胃顺应性和基础胃张力无明显影响，但可恢复胃的调节功能。与对照组相比，电针组餐后胃容量增加显著增强（275.0 +/- 45.8 vs. 180.8 +/- 54.3 ml; P < 0.02）。电针可恢复迷走神经切断术引起的胃调节功能受损，对胃轻瘫患者可能具有治疗潜力。
The aim of this study was to investigate the effects of electroacupuncture ( EA) on impaired gastric accommodation in a canine model. Ten dogs were chronically implanted with a gastric cannula in the stomach. Truncal vagotomy was performed in five of the dogs. Apolyethylene bag attached at the end of a catheter was placed in the proximal stomach via the cannula. Gastric compliance, gastric tone, and postprandial gastric accommodation were evaluated using a gastric barostat with and without EA on two separate days, respectively. Results were as follows. ( 1) The postprandial gastric volume increase was 180.8 +/- 54.3 ml in vagotomized dogs, which was significantly lower than that (317.3 +/- 37.3 ml; P < 0.05) in normal dogs. ( 2) In normal dogs, EA did not affect gastric compliance, basal gastric tone, or postprandial gastric accommodation. ( 3) In vagotomized dogs, EA did not affect gastric compliance or basal gastric tone but restored the impaired gastric accommodation. The postprandial gastric volume increase was significantly enhanced with EA compared to the control (275.0 +/- 45.8 vs. 180.8 +/- 54.3 ml; P < 0.02). EA restores impaired gastric accommodation induced by vagotomy and may have therapeutic potential for patients with gastroparesis.