Cat diencephalic neurons with sympathetic nerve-related activity.
Cat diencephalic neurons with sympathetic nerve-related activity.
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猫间脑神经元具有交感神经相关活动。
DOI：
10.1152/ajpregu.1988.254.2.r257
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Gebber,GL
中科院分区：
文献类型：
--
作者：
Varner,KJ;Barman,SM;Gebber,GL
在一篇配套论文中，我们证明下丘脑或内侧丘脑病变会减弱麻醉猫去大脑产生的下心脏节后交感神经放电（SND）的减少[Huang et al., Am. J.生理学。 254（监管综合比较生理学 23）：R249-R256，1988]。这提出了这些间脑区域含有导致 SND 的神经元细胞体的可能性。目前的研究在用α-氯醛糖麻醉的猫中测试了这种可能性。下心脏 SND 的尖峰触发平均值揭示了两种类型的下丘脑和内侧丘脑神经元的存在，它们具有交感神经相关的活动。记录是从这些神经元的体细胞树突区域进行的，因为拐点经常出现在单位动作电位的上升阶段。 1 型神经元的活动与 SND 中的非周期性尖峰事件同步，而 2 型神经元的活动与 2 至 6 Hz 的节律成分同步。一些 2 型神经元但没有 1 型神经元具有心脏相关活动。 1 型和 2 型单位记录位点的微刺激增加了 SND。我们的结果与下丘脑和内侧丘脑神经元对麻醉猫 SND 的节律性和非周期性成分有贡献的可能性是一致的。
In a companion paper, we demonstrated that hypothalamic or medial thalamic lesions attenuate the reduction in inferior cardiac postganglionic sympathetic nerve discharge (SND) produced by decerebration in the anesthetized cat [Huang et al., Am. J. Physiol. 254 (Regulatory Integrative Comp. Physiol. 23): R249-R256, 1988]. This raised the possibility that these diencephalic regions contain the cell bodies of neurons that contribute to SND. The current study tested this possibility in cats anesthetized with alpha-chloralose. Spike-triggered averaging of inferior cardiac SND revealed the existence of two types of hypothalamic and medial thalamic neurons with sympathetic nerve-related activity. Recordings were made from the soma-dendritic region of these neurons, since an inflection often appeared on the rising phase of the unit action potential. The activity of type 1 neurons was synchronized to an aperiodic spikelike event in SND, whereas that of type 2 neurons was synchronized to a 2- to 6-Hz rhythmic component. Some of the type 2 neurons but none of the type 1 neurons had cardiac-related activity. Microstimulation at type 1 and type 2 unit recording sites increased SND. Our results are consistent with the possibility that hypothalamic and medial thalamic neurons contribute to the rhythmic and aperiodic components of SND in the anesthetized cat.