Synthesis, Aromatization and Derivatization Reactions of 2-[9-( tert -Butoxycarbonyl)-4-oxo-1,5-dioxa-9-azaspiro[5.5]undec-2-en-2-yl]acetic Acid
Synthesis, Aromatization and Derivatization Reactions of 2-[9-( tert -Butoxycarbonyl)-4-oxo-1,5-dioxa-9-azaspiro[5.5]undec-2-en-2-yl]acetic Acid
复制标题
2-[9-(叔丁氧基羰基)-4-氧代-1,5-二氧杂-9-氮杂螺[5.5]十一碳-2-烯-2-基]乙酸的合成、芳构化和衍生化反应
DOI：
10.1002/ejoc.201901451
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发表时间：
2019
影响因子：
2.8
通讯作者：
Ma T
中科院分区：
文献类型：
--
作者：
Ma T
以aN‐Boc‐4‐oxo‐4H‐spiro[benzo[d][1，3]dioxinone‐2，4‐piperidine]，的一般衍生物为原料，仿生芳构化β，δ-二酮基二恶酮，再与香叶醇在烯酮偶联剂作用下合成了一系列天然产物螺环结构的间苯二酚、铬和铬酰胺类化合物。
A series of natural product inspired piperidines spiro‐fused with resorcylic, chromenic and chromanic amides were prepared from a general derivative of aN‐Boc‐4‐oxo‐4H‐spiro[benzo[d][1,3]dioxinone‐2,4‐piperidine], which was prepared through biomimetic aromatization of a β,δ‐diketo dioxinone, in turn synthesized fromN‐Boc‐4‐piperidone and geraniol using ketene coupling reagents.